지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The adjuvant effects of Korean mistletoe lectin-C (KML-C) were investigated following the oral administration of KML-C with ovalbumin (OVA) as an antigen. Mice were orally immunized with OVA alone or admixed with various doses of KML-C or cholera toxin (CT), and the titer of OVA-specific antibody in the serum and mucosal secretions were determined. OVA+KML-C-treated mice showed high titers of IgA specific to CT in mucosal secretions. The antibody titers in the serum of OVA+KML-C-treated mice were comparable to those in the serum of OVA+CT-treated mice. When mice were immunized with OVA+KML-C or with CT alone and subsequently injected with OVA on the footpads after the primary immunization, they showed a more significant increase in delayed-type hypersensitivity reactions than when they were administered CT alone. These results suggest that KML-C is a potent immunoadjuvant that enhances both humoral and cellular immunity by the mucosal immune system.
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Abstract
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참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Stern ME / 2010 / Autoimmunity at the ocular surface: Pathogenesis and regulation / Mucosal Immunol 3 : 425 ~ 442
2. [학술지(정기간행물)] - Kelsall BL / 2008 / A focus on dendritic cells and macrophages as key regulators of mucosal immunity / Mucosal Immunol 1 : 423 ~ 424
3. [학술지(정기간행물)] - Flo J / 1996 / Reversible effects on B and T cells of the gut-associated lymphoid tissues in rats malnourished during suckling: Impaired induction of the immune response to intra-Peyer patches immunization with cholera toxin / Clin. Immunol. Immuno 80 : 147 ~ 154
4. [학술지(정기간행물)] - Hibi M / 2003 / Dendritic cells from spleen, mesenteric lymph node, and Peyer’s patch can induce the production of both IL-4 and IFN-gamma from primary cultures of naive CD4(+) T cells in a dose-dependent manner / Cytotechnology 43 : 49 ~ 55
5. [학술지(정기간행물)] - Lavelle EC / 2000 / Mucosal immunogenicity of plant lectins in mice / Immunology 99 : 30 ~ 37
2. [학술지(정기간행물)] - Kelsall BL / 2008 / A focus on dendritic cells and macrophages as key regulators of mucosal immunity / Mucosal Immunol 1 : 423 ~ 424
3. [학술지(정기간행물)] - Flo J / 1996 / Reversible effects on B and T cells of the gut-associated lymphoid tissues in rats malnourished during suckling: Impaired induction of the immune response to intra-Peyer patches immunization with cholera toxin / Clin. Immunol. Immuno 80 : 147 ~ 154
4. [학술지(정기간행물)] - Hibi M / 2003 / Dendritic cells from spleen, mesenteric lymph node, and Peyer’s patch can induce the production of both IL-4 and IFN-gamma from primary cultures of naive CD4(+) T cells in a dose-dependent manner / Cytotechnology 43 : 49 ~ 55
5. [학술지(정기간행물)] - Lavelle EC / 2000 / Mucosal immunogenicity of plant lectins in mice / Immunology 99 : 30 ~ 37
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UCI(KEPA) : I410-ECN-0101-2013-573-001545783