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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.3
- 수록면
- 47 - 54 (8page)
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이 논문의 연구 히스토리 (2)
2012
Synergistic effect of interventional forced exercise on melatonin treated restoration of brain-cord networks after focal cerebral ischemia in rats
Seunghoon Lee
,
Yonggeun Hong
한국실험동물학회 학술발표대회 논문집
2012.08
학술대회자료
Beneficial effects of melatonin on stroke-induced muscle atrophy in focal cerebral ischemic rats
Seunghoon Lee
,
Jinhee Shin
,
Yunkyung Hong
외 5명
Laboratory Animal Research
2012.03
학술저널
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초록· 키워드
오류제보하기
Muscle atrophy is the result of two opposing conditions that can be found in pathological or diseased muscles: an imbalance in protein synthesis and degradation mechanisms. Thus, we investigated whether exogenous melatonin could regulate muscle components in stroke-induced muscle atrophy in rats. Comparing muscle phenotypes, we found that long-term melatonin administration could influence muscle mass. Muscle atrophy-related genes, including muscle atrophy F-box (MAFbx) and muscle ring finger 1 (MuRF1) were significantly down-regulated in melatonin-administered rats in the gastrocnemius. However, only MAFbx at the mRNA level was attenuated in the soleus of melatonin-administered rats. Insulin-like growth factor-1 receptor (IGF-1R) was significantly over-expressed in melatonin-administered rats in both the gastrocnemius and soleus muscles. Comparing myosin heavy chain (MHC) components, in the gastrocnemius, expression of both slow- and fast-type isoforms were significantly enhanced in melatoninadministered rats. These results suggest that long-term exogenous melatonin administration may have a prophylactic effect on muscle atrophy through the MuRF1/MAFbx signaling pathway, as well as a potential therapeutic effect on muscle atrophy through the IGF-1-mediated hypertrophic signaling pathway in a stroke animal model.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (27)
참고문헌 신청
Jackman RW / 2004 / The molecular basis of skeletal muscle atrophy / Am J Physiol Cell Physiol 287(4):834~843
Kasper CE / 2002 / Skeletal muscle damage and recovery / AACN Clin Issues 13(2):237~247
Tischler ME / 1993 / Spaceflight on STS-48 and earth-based unweighting produce similar effects on skeletal muscle of young rats / J Appl Physiol 74(5):2161~2165
Zeman RJ / 2009 / Differential skeletal muscle gene expression after upper or lower motor neuron transection / Pflugers Arch 458(3):525~535
Drummond MJ / 2008 / Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle / Muscle Nerve 37(4):505~513
Kasper CE / 2002 / Skeletal muscle damage and recovery / AACN Clin Issues 13(2):237~247
Tischler ME / 1993 / Spaceflight on STS-48 and earth-based unweighting produce similar effects on skeletal muscle of young rats / J Appl Physiol 74(5):2161~2165
Zeman RJ / 2009 / Differential skeletal muscle gene expression after upper or lower motor neuron transection / Pflugers Arch 458(3):525~535
Drummond MJ / 2008 / Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle / Muscle Nerve 37(4):505~513
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UCI(KEPA) : I410-ECN-0101-2013-510-001698931