지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.17 No.1
- 발행연도
- 2012.3
- 수록면
- 14 - 21 (8page)
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초록· 키워드
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The purpose of this study was to investigate the anti-allergy activities of persimmon leaf extract (PLE) on a phthalic anhydride (PA)-induced allergic mouse model. A human leukemic mast cell line (HMC-1) was used to examine the inhibitory activity of PLE on the histamine release by human leukemic mast cells. PLE inhibited histamine release from HMC-1 cells in response to cross-linkage of high-affinity IgE receptor-α (FcεRIα). Additionally, a PA-induced allergic mouse model was used to investigate the effects of PLE in vivo. Mice were orally administrated with or without PLE of single dose (250 ㎎/㎏/day) for 31 days. Oral intake of PLE significantly inhibited passive cutaneous reactions. Oral administration of PLE to PA-induced allergic mice also led to a striking suppression of the development of contact dermatitis, ear swelling and lymph node weight. In addition, PA-specific IL-4 production of draining lymph node cells was markedly diminished by PLE oral administration, but not IFN-γ. Furthermore, PLE treatment suppressed PA-induced thymus and activation-regulated chemokine (CCL17) and cutaneous T cell-attracting chemokine (CCL27) expressions in ear tissues. Based on these results, we suggest that PLE may have therapeutic potential as an effective material for management of irritant contact dermatitis or related inflammatory diseases.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (29)
참고문헌 신청
Ban M / 2005 / Effect of Th2 cytokine antagonist treatments on chemical-induced allergic response in mice / J Appl Toxicol 25:239~247
Kay AB. / 2001 / Allergy and allergic diseases. First of two parts / N Engl J Med 344:30~37
Incorvaia C / 2008 / Allergy and the skin / Clin Exp Immunol 153(Suppl 1):27~29
Hirota R / 2010 / Anti-inflammatory effects of limonene from yuzu (Citrus junos Tanaka) essential oil on eosinophils / J Food Sci 75:H87~H92
Zhang Y / 1997 / Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response / Am J Respir Crit Care Med 155:661~669
Kay AB. / 2001 / Allergy and allergic diseases. First of two parts / N Engl J Med 344:30~37
Incorvaia C / 2008 / Allergy and the skin / Clin Exp Immunol 153(Suppl 1):27~29
Hirota R / 2010 / Anti-inflammatory effects of limonene from yuzu (Citrus junos Tanaka) essential oil on eosinophils / J Food Sci 75:H87~H92
Zhang Y / 1997 / Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response / Am J Respir Crit Care Med 155:661~669
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UCI(KEPA) : I410-ECN-0101-2013-511-001729234