지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.3
- 수록면
- 1 - 4 (4page)
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초록· 키워드
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Bee venom (Apis mellifera L., BV) has been used as a cosmetic ingredient for antiaging, anti-inflammatory and antibacterial functions. The aim of this study was to access the skin sensitization of BV, a Buehler test was conducted fifty healthy male Hartley guinea pigs with three groups; Group G1 (BVsensitization group, 20 animals), group G2 (the positive control-sensitization group, 20 animals), and group G3 (the ethyl alcohol-sensitization group, 10 animals). The exposure on the left flank for induction was repeated three times at intervals of one week. Two weeks after the last induction, the challenge was performed on the right flank. No treatment-related clinical signs or body weight changes were observed during the study period. The average skin reaction evaluated by erythema and edema on the challenge sites and sensitization rate in the BV-sensitization group at 30 hours were 0.0 and 0%, respectively, which are substantially low compared with in positive control group (average skin reaction: 0.55, sensitization rate: 40%) and identical with in vehicle control group, representing a weak sensitizing potential. The average skin reaction and sensitization rate observed at 54 hours were 0.0 and 0% in the BV-sensitization group, respectively, and 0.25 and 20% in the positive control group, respectively. It was concluded that BV classified to Grade I, induced no sensitization when tested in guinea pigs and may provide a developmental basis for a cosmetic ingredient or external application for topical uses.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (17)
참고문헌 신청
Baek, Y. H. / 2006 / Antinociceptive effect and the mechanism of beevenom acupuncture (Apipuncture) on inflammatory pain in therat model of collagen-induced arthritis: Mediation by α2-adrenoceptors / Brain. Res 16:305~310
Castro, H. J. / 2005 / A Phase I Study of the safety of honeybee venom extract as a possible treatment for patients with progressive forms of multiple sclerosis / Allergy Asthma Pro 26:470~476
Chaudhry, Q. / 2010 / Global QSAR models of skin sensitisers for regulatory purposes / Chem. Cent. J. 4:5
Han, S. M. / 2007 / Inhibitory effect of bee venom against ultraviolet B induced MMP-1 and MMP-3 in human dermal fibroblasts / J. Apic. Res 46:94~98
Han, S. M. / 2007 / A simplified purificating method of bee venom,Patent, Korea, 10-0758814
Castro, H. J. / 2005 / A Phase I Study of the safety of honeybee venom extract as a possible treatment for patients with progressive forms of multiple sclerosis / Allergy Asthma Pro 26:470~476
Chaudhry, Q. / 2010 / Global QSAR models of skin sensitisers for regulatory purposes / Chem. Cent. J. 4:5
Han, S. M. / 2007 / Inhibitory effect of bee venom against ultraviolet B induced MMP-1 and MMP-3 in human dermal fibroblasts / J. Apic. Res 46:94~98
Han, S. M. / 2007 / A simplified purificating method of bee venom,Patent, Korea, 10-0758814
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UCI(KEPA) : I410-ECN-0101-2013-513-001729941