지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.3
- 수록면
- 33 - 38 (6page)
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초록· 키워드
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In this study, we investigated the effect of methanolic extract isolated from the root of Lycoris aurea (LA) on the growth of cancer cells and the tube formation activity of endothelial cells. Various cancer cells were treated with LA at doses of 0.3, 1, 3, 10 or 30 μg/ml and LA significantly suppressed the growth of several cancer cell lines, including ACHN, HCT-15, K-562, MCF-7, PC-3 and SK-OV-3, in a dose-dependent manner. We also found that LA induced cell cycle arrest at G2/M phase in ACHN renal cell adenocarcinoma cells. Further study demonstrated that LA concentration-dependently inhibited the tube formation, which is a widely used in vitro model of reorganization stage of angiogenesis, in human umbilical vein endothelial cells. Collectively, these results show that LA inhibits the growth of cancer cells and tube formation of endothelial cells and the growth-inhibitory effect of LA might be mediated, at least in part, by blocking cell cycle progression.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (20)
참고문헌 신청
Anand, P. / 2008 / Cancer is a preventable disease that requires major lifestyle changes / Pharm. Res 25:2097~2116
Banerjee, S. / 2011 / Attenuation of multi-targeted proliferationlinked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic / Mutat. Res 728:47~66
Chu, K.T / 2004 / First report of a glutamine-rich antifungal peptide with immunomodulatory and antiproliferative activities from family Amaryllidaceae / Biochem. Biophys. Res. Commun 325:167~173
Dibb, M / 2011 / Targeting the cell cycle in esophageal adenocarcinoma: an adjunct to anticancer treatment / World J. Gastroenterol 17:2063~2069
Goto, F. / 1993 / Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels / Lab. Invest 69:508~517
Banerjee, S. / 2011 / Attenuation of multi-targeted proliferationlinked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic / Mutat. Res 728:47~66
Chu, K.T / 2004 / First report of a glutamine-rich antifungal peptide with immunomodulatory and antiproliferative activities from family Amaryllidaceae / Biochem. Biophys. Res. Commun 325:167~173
Dibb, M / 2011 / Targeting the cell cycle in esophageal adenocarcinoma: an adjunct to anticancer treatment / World J. Gastroenterol 17:2063~2069
Goto, F. / 1993 / Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels / Lab. Invest 69:508~517
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UCI(KEPA) : I410-ECN-0101-2013-513-001729996