지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.4
- 수록면
- 153 - 160 (8page)
이용수
초록· 키워드
오류제보하기
Panax ginseng has long been used as a traditional herbal medicine. More recently, it has received attention for its anti-diabetic and anti-obesity effects in humans and in animal models of type 2 diabetes. In the present study, we tested the hypoglycemic effects of ginseng berry extract in beta-cell-defi cient mice and investigated the mechanisms involved. Red (ripe) and green (unripe) berry extracts were prepared and administered orally (100 or 200 ㎎/㎏ body weight) to streptozotocin-induced diabetic mice daily for 10 wk. The body weight was measured daily, and the nonfasting blood glucose levels were measured after 5 and 10 wk after administration. Glucose tolerance tests were performed, and the serum insulin levels were measured. The proliferation of betacells was measured in vitro. The administration of red or green ginseng berry extract signifi cantly reduced the blood glucose levels and improved the glucose tolerance in beta-cell defi cient mice, with the higher doses resulting in better effects. Glucose-stimulated insulin secretion was signifi cantly increased in berry extract-treated mice compared with streptozotocin-induced diabetic control mice. Treatment with ginseng berry extract increased beta-cell proliferation in vitro. Both red berry and green berry extracts improved glycemic control in streptozotocin-induced diabetic mice and increased insulin secretion, possibly due to increased betacell proliferation. These results suggest that ginseng berry extracts might have benefi cial effects on beta-cell regeneration.
목차
INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Ritzel RA. / 2009 / Therapeutic approaches based on beta-cell mass preservation and/or regeneration / Front Biosci 14 : 1835 ~ 1850
2. [학술지(정기간행물)] - Yoon JW / 2005 / Autoimmune destruction of pancreatic beta cells / Am J Ther 12 : 580 ~ 591
3. [학술지(정기간행물)] - Wajchenberg BL. / 2007 / Beta-cell failure in diabetes and preservation by clinical treatment / Endocr Rev 28 : 187 ~ 218
4. [학술지(정기간행물)] - Cheng Y / 2005 / Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action / Acta Pharmacol Sin 26 : 143 ~ 149
5. [학술지(정기간행물)] - 추민경 / 200306 / Antiallergic activity of ginseng and its ginsenosides / Planta Medica 69 (6) : 518 ~ 522
2. [학술지(정기간행물)] - Yoon JW / 2005 / Autoimmune destruction of pancreatic beta cells / Am J Ther 12 : 580 ~ 591
3. [학술지(정기간행물)] - Wajchenberg BL. / 2007 / Beta-cell failure in diabetes and preservation by clinical treatment / Endocr Rev 28 : 187 ~ 218
4. [학술지(정기간행물)] - Cheng Y / 2005 / Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action / Acta Pharmacol Sin 26 : 143 ~ 149
5. [학술지(정기간행물)] - 추민경 / 200306 / Antiallergic activity of ginseng and its ginsenosides / Planta Medica 69 (6) : 518 ~ 522
이 논문의 저자 정보
이 논문과 함께 이용한 논문
인삼열매 추출물의 혈행개선과 피부톤 개선에 미치는 영향
김정기
,
김병수
,
박찬웅
외 3명
동의생리병리학회지
2010
.02
울금(Curcuma longa L.)이 고지방·고콜레스테롤 식이 흰쥐의 항산화계 및 산화적 손상에 미치는 영향
김민선
,
전성식
,
최정화
한국식품영양과학회지
2013
.04
Protective Effect of Processed Panax ginseng, Sun Ginseng on UVB-irradiated Human Skin Keratinocyte and Human Dermal Fibroblast
Hyejin Lee
,
Joo Yeop Lee
,
Kyu Choon Song
외 5명
Journal of Ginseng Research
2012
.01
Effect of Polysaccharides from a Korean Red Ginseng Berry on the Immunosenescence of Aged Mice
Mi Seon Kim
,
Yohan Hong
,
Eun Ji Kim
외 8명
한국약용작물학회 학술대회논문집
2019
.10
Aβ42로 유도된 알츠하이머 마우스 모델에서 이중 가공 인삼열매 추출물의 학습 및 기억 손실 개선 효과
장수길
,
안정원
,
조보람
외 7명
한국식품과학회지
2019
.04
최근 본 자료
댓글(0)
0