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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.4
- 수록면
- 161 - 168 (8page)
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초록· 키워드
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The abnormal maturation and ossifi cation of articular chondrocytes play a central role in the pathogenesis of osteoarthritis (OA). Inhibiting the enzymatic degradation of the extracellular matrix and maintaining the cellular phenotype are two of the major goals of interest in managing OA. Ginseng is frequently taken orally, as a crude substance, as a traditional medicine in Asian countries. Ginsenoside Rb₁, a major component of ginseng that contains an aglycone with a dammarane skeleton, has been reported to exhibit various biological activities, including anti-infl ammatory and anti-tumor effects. However, a chondroprotective effect of ginsenoside Rb1 related to OA has not yet been reported. The purpose of this study was to demonstrate the chondroprotective effect of ginsenoside Rb1 on the regulation of pro-infl ammatory factors and chondrogenic genes. Cultured rat articular chondrocytes were treated with 100 μM ginsenoside Rb1 and/or 500 μM hydrogen peroxide (H2O2) and assessed for viability, reactive oxygen species production, nitric oxide (NO) release, and chondrogenic gene expression. Ginsenoside Rb1 treatment resulted in reductions in the levels of pro-infl ammatory cytokine and NO in H₂O₂-treated chondrocytes. The expression levels of chondrogenic genes, such as type Ⅱ collagen and SOX9, were increased in the presence of ginsenoside Rb1, whereas the expression levels of infl ammatory genes related to chondrocytes, such as MMP1 and MMP13, were reduced by approximately 50%. These results suggest that ginsenoside Rb₁ has potential for use as a therapeutic agent in OA patients.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Drissi H / 2005 / Transcriptional regulation of chondrocyte maturation : potential involvement of transcription factors in OA pathogenesis / Mol Aspects Med 26 : 169 ~ 179
2. [학술지(정기간행물)] - Matsumoto T / 2009 / Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1 / Arthritis Rheum 60 : 1390 ~ 1405
3. [학술지(정기간행물)] - Mathy-Hartert M / 2003 / Reactive oxygen species downregulate the expression of pro-inflammatory genes by human chondrocytes / Infl amm Res 52 : 111 ~ 118
4. [학술지(정기간행물)] - Asada S / 1999 / Effect of hydrogen peroxide on the metabolism of articular chondrocytes / Infl amm Res 48 : 399 ~ 403
5. [학술지(정기간행물)] - Jallali N / 2005 / Vulnerability to ROS-induced cell death in ageing articular cartilage : the role of antioxidant enzyme activity / Osteoarthritis Cartilage 13 : 614 ~ 622
2. [학술지(정기간행물)] - Matsumoto T / 2009 / Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1 / Arthritis Rheum 60 : 1390 ~ 1405
3. [학술지(정기간행물)] - Mathy-Hartert M / 2003 / Reactive oxygen species downregulate the expression of pro-inflammatory genes by human chondrocytes / Infl amm Res 52 : 111 ~ 118
4. [학술지(정기간행물)] - Asada S / 1999 / Effect of hydrogen peroxide on the metabolism of articular chondrocytes / Infl amm Res 48 : 399 ~ 403
5. [학술지(정기간행물)] - Jallali N / 2005 / Vulnerability to ROS-induced cell death in ageing articular cartilage : the role of antioxidant enzyme activity / Osteoarthritis Cartilage 13 : 614 ~ 622
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