지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.4
- 수록면
- 169 - 175 (7page)
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초록· 키워드
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Ginseng has been used as a traditional medicine for treatment of many diseases and for general health maintenance in people of all ages. Ginseng is also used to ameliorate menopausal systems. We investigated the estrogenic activity of Korean red ginseng (KRG) in a transient transfection system, using estrogen receptor (ER) and estrogen-responsive luciferase plasmids in MCF-7 cells. The extract activated both ERα and ERβ. KRG modulated the mRNA levels of estrogen-responsive genes such as pS2 and ESR1 and decreased the protein level of ERα. In order to examine in vivo estrogenic activity of KRG, sixteen female Sprague-Dawley rats separated into four groups were studied for nine weeks: non-ovariectomized (OVX) rats treated with olive oil, OVX rats treated with olive oil, OVX rats treated with 17-β-estradiol (E2) in olive oil, and OVX rats treated with KRG extract in olive oil. The experiments were repeated for three times and the data of twelve rats were combined. Body weight of OVX rats was greater than that of sham-operated control rats and was decreased by E2 treatment. Uterine weight increased after E2 treatment compared to OVX rats. However, no difference in body or uterine weight was observed with KRG intake. KRG induced reductions in total cholesterol, low density lipoprotein cholesterol/total cholesterol, high density lipoprotein cholesterol/total cholesterol, and low density lipoprotein cholesterol/high density lipoprotein cholesterol, but not to the same degree as did E2 intake. These results show that KRG does contain estrogenic activity as manifested by in vitro study but the activity is not strong enough to elicit physiological responses.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Doyle BJ / 2009 / Estrogenic effects of herbal medicines from Costa Rica used for the management of menopausal symptoms / Menopause 16 : 748 ~ 755
2. [학술지(정기간행물)] - Lissin LW / 2000 / Phytoestrogens and cardiovascular health / J Am Coll Cardiol 35 : 1403 ~ 1410
3. [학술지(정기간행물)] - Kallen AN / 2011 / Cardiovascular disease and ovarian function / Curr Opin Obstet Gynecol 23 : 258 ~ 267
4. [학술지(정기간행물)] - Yanes LL / 2011 / Postmenopausal hypertension / Am J Hypertens 24 : 740 ~ 749
5. [학술지(정기간행물)] - King J / 2011 / Hormone replacement therapy and women with premature menopause--a cancer survivorship issue / Eur J Cancer 47 : 1623 ~ 1632
2. [학술지(정기간행물)] - Lissin LW / 2000 / Phytoestrogens and cardiovascular health / J Am Coll Cardiol 35 : 1403 ~ 1410
3. [학술지(정기간행물)] - Kallen AN / 2011 / Cardiovascular disease and ovarian function / Curr Opin Obstet Gynecol 23 : 258 ~ 267
4. [학술지(정기간행물)] - Yanes LL / 2011 / Postmenopausal hypertension / Am J Hypertens 24 : 740 ~ 749
5. [학술지(정기간행물)] - King J / 2011 / Hormone replacement therapy and women with premature menopause--a cancer survivorship issue / Eur J Cancer 47 : 1623 ~ 1632
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