지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.2
- 수록면
- 90 - 95 (6page)
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Purpose: Ductal carcinoma in situ (DCIS), unlike invasive ductal carcinoma, does not require sentinel lymph node biopsy or axillary lymph node dissection because the possibility of axillary lymph node metastasis is low. However, occasionally, despite preoperative diagnosis of DCIS, invasive ductal carcinoma can be diagnosed by postoperative biopsy. Therefore, a study of the associated risk factors is necessary.
Methods: 198 patients with an initial diagnosis of DCIS, treated between February 2005 and December 2009, were retrospectively analyzed. Associations between clinical and pathologic factors were analyzed for significance using univariate and multivariate analyses.
Results: Of the 198 patients, 57 (28.8%) were found to have invasive disease on final pathology. Multivariate analysis revealed 4 independent predictors of invasive cancer upon final pathology: diagnosis by needle biopsy (OR, 3.165; P=0.008), positive p53 on preoperative biopsy (OR, 2.494; P=0.019) DCIS size (＞2 ㎝) on microscopic finding (OR, 2.683; P=0.014), and relatively young age (OR, 0.958, P=0.046). Of the 13 patients with positive axillary lymph nodes, 11 (84.6%) were shown to have invasive cancer on final pathology (P＜0.001).
Conclusion: In cases of preoperative diagnosis based on needle biopsy, positive p53, large tumor, and relatively young age, an SLNB procedure can be considered because in almost 30% of the patients an invasive carcinoma is found after surgery.
Methods: 198 patients with an initial diagnosis of DCIS, treated between February 2005 and December 2009, were retrospectively analyzed. Associations between clinical and pathologic factors were analyzed for significance using univariate and multivariate analyses.
Results: Of the 198 patients, 57 (28.8%) were found to have invasive disease on final pathology. Multivariate analysis revealed 4 independent predictors of invasive cancer upon final pathology: diagnosis by needle biopsy (OR, 3.165; P=0.008), positive p53 on preoperative biopsy (OR, 2.494; P=0.019) DCIS size (＞2 ㎝) on microscopic finding (OR, 2.683; P=0.014), and relatively young age (OR, 0.958, P=0.046). Of the 13 patients with positive axillary lymph nodes, 11 (84.6%) were shown to have invasive cancer on final pathology (P＜0.001).
Conclusion: In cases of preoperative diagnosis based on needle biopsy, positive p53, large tumor, and relatively young age, an SLNB procedure can be considered because in almost 30% of the patients an invasive carcinoma is found after surgery.
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REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - The Korean Breast Cancer Society / 2004 / Nationwide Korean breast cancer data of 2002 / J Korean Breast Cancer Soc 7 : 72 ~ 83
2. [학술지(정기간행물)] - Pendas S / 2000 / Sentinel node biopsy in ductal carcinoma in situ patients / Ann Surg Oncol 7 : 15 ~ 20
3. [학술지(정기간행물)] - Zelis JJ / 2002 / Do not contemplate invasive surgery for ductal carcinoma in situ / Am J Surg 184 : 348 ~ 349
4. [학술지(정기간행물)] - Leonard GD / 2004 / Ductal carcinoma in situ, complexities and challenges / J Natl Cancer Inst 96 : 906 ~ 920
5. [학술지(정기간행물)] - Morrow M / 2001 / Prospective comparison of stereotactic core biopsy and surgical excision as diagnostic procedures for breast cancer patients / Ann Surg 233 : 537 ~ 541
2. [학술지(정기간행물)] - Pendas S / 2000 / Sentinel node biopsy in ductal carcinoma in situ patients / Ann Surg Oncol 7 : 15 ~ 20
3. [학술지(정기간행물)] - Zelis JJ / 2002 / Do not contemplate invasive surgery for ductal carcinoma in situ / Am J Surg 184 : 348 ~ 349
4. [학술지(정기간행물)] - Leonard GD / 2004 / Ductal carcinoma in situ, complexities and challenges / J Natl Cancer Inst 96 : 906 ~ 920
5. [학술지(정기간행물)] - Morrow M / 2001 / Prospective comparison of stereotactic core biopsy and surgical excision as diagnostic procedures for breast cancer patients / Ann Surg 233 : 537 ~ 541
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