지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.2
- 수록면
- 111 - 118 (8page)
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Purpose: The purpose of this study is to identify useful clinicopathologic factors for the prediction of lymph node metastasis in submucosally invasive colorectal carcinoma.
Methods: A total of fifty-four cases of colorectal carcinomas with submucosal invasion were included. The patients underwent curative resection with en bloc lymph node dissection. Clinical features such as age, gender, tumor size and tumor location were reviewed. Histopathologic examinations for tumor growth type, differentiation, depth of tumor invasion, lymphovascular invasion, neural invasion, tumor budding and peritumoral inflammation were performed. The expression of E-cadherin, β-catenin, Smad4, p53 and Ki-67 were examined by immunohistochemistry. The correlation between the clinicopathologic factors and lymph node metastasis was evaluated.
Results: From the 54 patients with submucosally invasivecolorectal carcinoma, lymph node metastasis was identified in 13 cases (24.1%). The incidence of lymph node metastasis was significantly higher in cases positive for lymphovascular invasion (55.6% vs. 17.8%, P=0.028) and positive for tumor budding (47.4% vs. 11.45%, P=0.006). Cases negative for Smad4 had a higher tendency for incidence of lymph node metastasis (28.6% vs. 15.8%, P=0.341). Other clinicopathologic and immunohistochemical features were irrelevant to the lymph node status. In multivariate analysis, only tumor budding was an independent predictor of lymph node metastasis (P=0.051).
Conclusion: Lymphovascular invasion and tumor budding were predictive factors of lymph node metastasis in submucosally invasive colorectal carcinoma. The incidence of lymph node metastasis of submucosally invasive colorectal carcinoma was not low. Careful selection for avoiding surgery in submuocally invasive colorectal carcinoma should be considered.
Methods: A total of fifty-four cases of colorectal carcinomas with submucosal invasion were included. The patients underwent curative resection with en bloc lymph node dissection. Clinical features such as age, gender, tumor size and tumor location were reviewed. Histopathologic examinations for tumor growth type, differentiation, depth of tumor invasion, lymphovascular invasion, neural invasion, tumor budding and peritumoral inflammation were performed. The expression of E-cadherin, β-catenin, Smad4, p53 and Ki-67 were examined by immunohistochemistry. The correlation between the clinicopathologic factors and lymph node metastasis was evaluated.
Results: From the 54 patients with submucosally invasivecolorectal carcinoma, lymph node metastasis was identified in 13 cases (24.1%). The incidence of lymph node metastasis was significantly higher in cases positive for lymphovascular invasion (55.6% vs. 17.8%, P=0.028) and positive for tumor budding (47.4% vs. 11.45%, P=0.006). Cases negative for Smad4 had a higher tendency for incidence of lymph node metastasis (28.6% vs. 15.8%, P=0.341). Other clinicopathologic and immunohistochemical features were irrelevant to the lymph node status. In multivariate analysis, only tumor budding was an independent predictor of lymph node metastasis (P=0.051).
Conclusion: Lymphovascular invasion and tumor budding were predictive factors of lymph node metastasis in submucosally invasive colorectal carcinoma. The incidence of lymph node metastasis of submucosally invasive colorectal carcinoma was not low. Careful selection for avoiding surgery in submuocally invasive colorectal carcinoma should be considered.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Kashida H / 2006 / Early colorectal cancer: concept, diagnosis, and management / Int J Clin Oncol 11 : 1 ~ 8
2. [학술지(정기간행물)] - Hurlstone DP / 2004 / Colonoscopic resection of lateral spreading tumors: a prospective analysis of endoscopic mucosal resection / Gut 53 : 1334 ~ 1339
3. [학술지(정기간행물)] - Christopher B / 2000 / Endoscopic management of polypoid early colon cancer / World J Surg 24 : 1047 ~ 1051
4. [학술지(정기간행물)] - Fujimori T / 2001 / Precancerous lesion of the colorectum / J Gastroenterol 36 : 587 ~ 594
5. [학술지(정기간행물)] - Cranley JP / 1986 / When is endoscopic polypectomy adequate therapy for colonic polyps containing invasive carcinoma / Gastroenterology 91 : 419 ~ 427
2. [학술지(정기간행물)] - Hurlstone DP / 2004 / Colonoscopic resection of lateral spreading tumors: a prospective analysis of endoscopic mucosal resection / Gut 53 : 1334 ~ 1339
3. [학술지(정기간행물)] - Christopher B / 2000 / Endoscopic management of polypoid early colon cancer / World J Surg 24 : 1047 ~ 1051
4. [학술지(정기간행물)] - Fujimori T / 2001 / Precancerous lesion of the colorectum / J Gastroenterol 36 : 587 ~ 594
5. [학술지(정기간행물)] - Cranley JP / 1986 / When is endoscopic polypectomy adequate therapy for colonic polyps containing invasive carcinoma / Gastroenterology 91 : 419 ~ 427
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