지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.5
- 수록면
- 352 - 360 (9page)
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Purpose: Researching the inhibitors of the gene products that participate in the multistep carcinogenetic events of human cancer is important for chemoprevention or adjuvant cancer therapy. This study was performed to search for basic data for the chemoprevention or adjuvant therapy of human hepatobiliary and pancreatic adenocarcinoma, and we wanted to evaluate the coexpression of each gene product and the relationship between the expression of each gene product and the clinocopathologic factors and the prognosis.
Methods: The following formalin-fixed paraffin embedded surgical specimens were immunohistochemically stained by the avidin-biotin complex method for C-erbB-2, COX-2, MMP-9, p53 and VEGF. There were 15 cases of intrahepatic cholangiocarcinoma, 12 cases of metastatic adenocarcinoma in the liver, 15 cases of gallbladder adenocarcinoma, 25 cases of extrahepatic bile duct adnocarcinoma involving the ampullary region and 20 cases of pancreatic ductal adenocarcinoma.
Results: Varying frequencies of the overexpressions of the five gene products in the hepatobiliary and pancreatic adenocarcinomas were noted. Although the coexpression of the five gene products was observed to various degrees, the VEGF expression was statistically correlated with the expressions of COX-2 (in the intrahepatic cholangiocarcinoma) MMP-9 (in the glalbladder adenocarcinoma) and p53 (in the extrahepatic bile duct and pancreatic duct adenocarcinoma) (P＜0.05). There was also statistical correlation between the C-erbB-2 and COX-2 expressions and the clinical stage of adenocarcinoma of the extrahepatic bile ducts (P＜0.05).
Conclusion: These results suggest that the overexpression of the five gene products was one of the important multistep carcinogenetic events, and the VEGF expression might play an important role in the coexpression of other gene products of hepatobiliary and pancreatic adenocarcinoma.
Methods: The following formalin-fixed paraffin embedded surgical specimens were immunohistochemically stained by the avidin-biotin complex method for C-erbB-2, COX-2, MMP-9, p53 and VEGF. There were 15 cases of intrahepatic cholangiocarcinoma, 12 cases of metastatic adenocarcinoma in the liver, 15 cases of gallbladder adenocarcinoma, 25 cases of extrahepatic bile duct adnocarcinoma involving the ampullary region and 20 cases of pancreatic ductal adenocarcinoma.
Results: Varying frequencies of the overexpressions of the five gene products in the hepatobiliary and pancreatic adenocarcinomas were noted. Although the coexpression of the five gene products was observed to various degrees, the VEGF expression was statistically correlated with the expressions of COX-2 (in the intrahepatic cholangiocarcinoma) MMP-9 (in the glalbladder adenocarcinoma) and p53 (in the extrahepatic bile duct and pancreatic duct adenocarcinoma) (P＜0.05). There was also statistical correlation between the C-erbB-2 and COX-2 expressions and the clinical stage of adenocarcinoma of the extrahepatic bile ducts (P＜0.05).
Conclusion: These results suggest that the overexpression of the five gene products was one of the important multistep carcinogenetic events, and the VEGF expression might play an important role in the coexpression of other gene products of hepatobiliary and pancreatic adenocarcinoma.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (38)
참고문헌 신청
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Taketo MM , 1998 , Cyclooxygenase-2 inhibitors in tumorigenesis , J Natl Cancer Inst 90 : 1529 ~ 1536
Subbaramaiah K , 1996 , Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells , Cancer Res 56 : 4424 ~ 4429
Izumi Y , 2002 , Tumour biology: herceptin acts as an anti-angiogenetic cocktail , Nature 416 : 279 ~ 280
Keck PJ , 1989 , Vascular permeability factor, an endothelial cell mitogen related to PDGF , Science 246 : 1309 ~ 1311
Taketo MM , 1998 , Cyclooxygenase-2 inhibitors in tumorigenesis , J Natl Cancer Inst 90 : 1529 ~ 1536
Subbaramaiah K , 1996 , Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells , Cancer Res 56 : 4424 ~ 4429
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