지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.4
- 수록면
- 238 - 245 (8page)
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Purpose: Small-for-size syndrome (SFSS) is a major problem in liver surgery, and splenectomy has been used to prevent SFSS. However, it is unknown whether splenectomy has the same effect on liver regeneration in both standard and marginal hepatectomy. The aim of this study is to see a difference in effect of splenectomy on liver regeneration according to the amount of liver resection. Methods: Thirty male Sprague-Dawley rats (220 to 260 g) were divided into the following five groups: control (n = 6), 70% hepatectomy (n = 6), 70% hepatectomy with splenectomy (n = 6), 90% hepatectomy (n = 6), and 90% hepatectomy with splenectomy (n = 6). The animals were euthanized 24 hours after surgery and liver specimens were obtained. To assess liver regeneration, we performed immunohistochemistry of liver tissue using 5-bromo-2-deoxyuridine (BrdU) labeling and Western blot analysis of hepatic growth factor (HGF) and transforming growth factor-β (TGF-β) in the liver tissue. Results: The splenectomized subgroup had a higher BrdU-positive cell count in the 90% hepatectomy group, but not in the 70% hepatectomy group (P ＜ 0.001). Splenectomy significantly decreased TGF-β expression (P = 0.005) and increased the HGF to TGF-β ratio (P = 0.002) in the 90% hepatectomy group, but not in the 70% hepatectomy group. Conclusion: The positive effect of splenectomy on liver regeneration was greater in the group with the larger liver resection. This phenomenon may be related to the relative balance between HGF and TGF-β in the liver.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Clavien PA / 2007 / Strategies for safer liver surgery and partial liver transplantation / N Engl J Med 356 : 1545 ~ 1559
2. [학술지(정기간행물)] - Dahm F / 2005 / Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications / Am J Transplant 5 : 2605 ~ 2610
3. [학술지(정기간행물)] - Marubashi S / 2007 / Impact of graft size on postoperative thrombocytopenia in living donor liver transplant / Arch Surg 142 : 1054 ~ 1058
4. [학술지(정기간행물)] - Saner F / 2005 / Small-for-size syndrome after living-donor liver transplantation treated by "portal vein wrapping" and single plasmapheresis / Transplantation 79 : 625 ~
5. [학술지(정기간행물)] - Troisi R / 2005 / Effects of hemi-portocaval shunts for inflow modulation on the outcome of small-for-size grafts in living donor liver transplantation / Am J Transplant 5 : 1397 ~ 1404
2. [학술지(정기간행물)] - Dahm F / 2005 / Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications / Am J Transplant 5 : 2605 ~ 2610
3. [학술지(정기간행물)] - Marubashi S / 2007 / Impact of graft size on postoperative thrombocytopenia in living donor liver transplant / Arch Surg 142 : 1054 ~ 1058
4. [학술지(정기간행물)] - Saner F / 2005 / Small-for-size syndrome after living-donor liver transplantation treated by "portal vein wrapping" and single plasmapheresis / Transplantation 79 : 625 ~
5. [학술지(정기간행물)] - Troisi R / 2005 / Effects of hemi-portocaval shunts for inflow modulation on the outcome of small-for-size grafts in living donor liver transplantation / Am J Transplant 5 : 1397 ~ 1404
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UCI(KEPA) : I410-ECN-0101-2013-514-002677178