지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.3
- 수록면
- 177 - 183 (7page)
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초록· 키워드
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Purpose: Recent studies have shown that cyclooxygenase (COX)-2 may be involved in colorectal carcinogenesis. In this study, we evaluate the differences of COX-2 expression in patients with synchronous and metachronous hepatic metastasis of colorectal cancer. In addition, the expression of COX-1 and E-cadherin were also evaluated.
Methods: Paraffin embedded blocks were obtained from 41 patients who underwent surgery for colorectal cancer with hepatic metastasis. Samples from primary colorectal cancer, synchronous and metachronous hepatic lesions were stained by immunohistochemistry for monoclonal antibody against COX-1, COX-2, and E-cadherin.
Results: In colonic COX-1 expression, there was no significant difference in the degree of COX-1 expression between primary colorectal cancer with synchronous hepatic metastasis and that of metachronous hepatic metastasis (P=0.507). In colonic COX-2 and E-cadherin expression, the degree of COX-2 expression was not different between the two groups. But, the patient survival rate in the positive group of COX-1 and COX-2 expression was lower than in the negative group, respectively (P=0.023, P=0.006).
Conclusion: The degree of colonic COX-1 and COX-2 expression has an impact on prognosis in synchronous and metachronous hepatic metastasis. Further large-scale study is necessary to determine the meaning of COX-2 expression in colorectal cancer.
Methods: Paraffin embedded blocks were obtained from 41 patients who underwent surgery for colorectal cancer with hepatic metastasis. Samples from primary colorectal cancer, synchronous and metachronous hepatic lesions were stained by immunohistochemistry for monoclonal antibody against COX-1, COX-2, and E-cadherin.
Results: In colonic COX-1 expression, there was no significant difference in the degree of COX-1 expression between primary colorectal cancer with synchronous hepatic metastasis and that of metachronous hepatic metastasis (P=0.507). In colonic COX-2 and E-cadherin expression, the degree of COX-2 expression was not different between the two groups. But, the patient survival rate in the positive group of COX-1 and COX-2 expression was lower than in the negative group, respectively (P=0.023, P=0.006).
Conclusion: The degree of colonic COX-1 and COX-2 expression has an impact on prognosis in synchronous and metachronous hepatic metastasis. Further large-scale study is necessary to determine the meaning of COX-2 expression in colorectal cancer.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Bengmark S / 1969 / The natural history of primary and secondary malignant tumors of the liver. I. The prognosis for patients with hepatic metastases from colonic and rectal carcinoma by laparotomy / Cancer 23 : 198 ~ 202
2. [학술지(정기간행물)] - Abdalla EK / 2004 / Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ ablation for colorectal liver metastases / Ann Surg 239 : 818 ~ 827
3. [학술지(정기간행물)] - Ohlsson B / 1998 / Resection of colorectal liver metastases: 25-year experience / World J Surg 22 : 268 ~ 277
4. [학술지(정기간행물)] - Ekberg H / 1987 / Pattern of recurrence in liver resection for colorectal secondaries / World J Surg 11 : 541 ~ 547
5. [학술지(정기간행물)] - Bozzetti F / 1987 / Patterns of failure following surgical resection of colorectal cancer liver metastases. Rationale for a multimodal approach / Ann Surg 205 : 264 ~ 270
2. [학술지(정기간행물)] - Abdalla EK / 2004 / Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ ablation for colorectal liver metastases / Ann Surg 239 : 818 ~ 827
3. [학술지(정기간행물)] - Ohlsson B / 1998 / Resection of colorectal liver metastases: 25-year experience / World J Surg 22 : 268 ~ 277
4. [학술지(정기간행물)] - Ekberg H / 1987 / Pattern of recurrence in liver resection for colorectal secondaries / World J Surg 11 : 541 ~ 547
5. [학술지(정기간행물)] - Bozzetti F / 1987 / Patterns of failure following surgical resection of colorectal cancer liver metastases. Rationale for a multimodal approach / Ann Surg 205 : 264 ~ 270
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UCI(KEPA) : I410-ECN-0101-2013-514-002679758