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논문 기본 정보

자료유형
학술저널
저자정보
Kyong-Hwa Jun (가톨릭대학교) Yong-Sung Won (가톨릭대학교) Gun-Hyung Na (가톨릭대학교) Young-Jin Suh (가톨릭대학교) Hyun-Min Cho (가톨릭대학교) Woo-Bae Park (가톨릭대학교) Hyung-Min Chin (가톨릭대학교) Chung-Soo Chun (가톨릭대학교)
저널정보
대한외과학회 Annals of Surgical Treatment and Research 대한외과학회지 Vol.73 No.5
발행연도
2007.11
수록면
392 - 399 (8page)

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Purpose: E-cadherin (ECD) plays a pivotal role in integrating the normal tissue architecture and the suppression of cancer invasion, including stomach cancer. The epidemiology of stomach cancers is noticeably different according to the site of the index tumor, even though the stomach cancers all have similar gross shapes. In this study, the relation between the expression of ECD, along with the clinicopathologic parameters and recurrence or survival, were investigated for patients with gastric adenocarcinoma according to the tumor location.
Methods: We examined formalin-fixed, paraffin-embedded archival tissues from 50 surgically resectable gastric adenocarcinomas, which were grouped by the index tumor site as follows: distal (antrum) versus proximal (mid and upper body). To elucidate the correlation between the ECD expression and the site of the stomach cancer with the other clinicopathologic factors, we examined the ECD tissue status via performing immunohistochemistry. To compare the rates of recurrence and survival among subgroups, the patients were followed up for an average of 42 months.
Results: Among the 50 tumors examined, 28 (56%) tumors showed various degrees of a ECD expression. The gender, age, size, depth of invasion, lymph node metastasis, stage, lymphatic invasion and vascular invasion were not related with the ECD expression. The Lauren classification was correlated with the ECD expression in the mid and upper body stomach cancer, but not in the antral stomach cancer (P=0.042). The expression of ECD was not related with the survival rate (P=0.223). There was no significant difference in the recurrence rate between the subgroups with and without an abnormal expression of ECD (P=0.588).
Conclusion: For the mid and upper body stomach cancer, the expression of E-cadherin correlated with the diffuse type of cancer, according to the Lauren classification, but not with the survival rate.

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INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2013-514-002683027