지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.10
- 수록면
- 276 - 280 (5page)
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초록· 키워드
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Multiple jejunalgastrointestinal stromal tumors (GISTs) were found in a 52-year-old woman with a history of neurofibromatosis type 1. These tumors were composed of interlacing fascicles of uniform spindle cells with eosinophilic cytoplasm. Immunohistochemically, the tumor cells were positive for CD117, CD34 and negative for S-100, smooth muscle actin. Molecular analysis for activating mutations of KIT and PDGFRA was performed in two tumors. Contrary to sporadic GISTs, the NF1-associated GISTs are characterized by rare mutations of KIT or PDGFRA. But, one missense point mutation (Trp557Gly) was identified in KIT exon 11 of the extramural portion of the largest tumor in this case. The intramural portion of the largest tumor and the other tumor had wild type KIT and PDGFRA.
목차
INTRODUCTION
CASE REPORT
DISCUSSION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (10)
참고문헌 신청
1. [학술지(정기간행물)] - Miettinen M / 2006 / Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases / Am J Surg Pathol 30 : 90 ~ 96
2. [학술지(정기간행물)] - Maertens O / 2006 / Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients / Hum Mol Genet 15 : 1015 ~ 1023
3. [학술지(정기간행물)] - Takazawa Y / 2005 / Gastrointestinal stromal tumors of neurofibromatosis type I (von Recklinghausen's disease) / Am J Surg Pathol 29 : 755 ~ 763
4. [학술지(정기간행물)] - Cheng SP / 2004 / Neurofibromatosis with gastrointestinal stromal tumors: insights into the association / Dig Dis Sci 49 : 1165 ~ 1169
5. [학술지(정기간행물)] - Yantiss RK / 2005 / Multiple gastrointestinal stromal tumors in type I neurofibromatosis: a pathologic and molecular study / Mod Pathol 18 : 475 ~ 484
2. [학술지(정기간행물)] - Maertens O / 2006 / Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients / Hum Mol Genet 15 : 1015 ~ 1023
3. [학술지(정기간행물)] - Takazawa Y / 2005 / Gastrointestinal stromal tumors of neurofibromatosis type I (von Recklinghausen's disease) / Am J Surg Pathol 29 : 755 ~ 763
4. [학술지(정기간행물)] - Cheng SP / 2004 / Neurofibromatosis with gastrointestinal stromal tumors: insights into the association / Dig Dis Sci 49 : 1165 ~ 1169
5. [학술지(정기간행물)] - Yantiss RK / 2005 / Multiple gastrointestinal stromal tumors in type I neurofibromatosis: a pathologic and molecular study / Mod Pathol 18 : 475 ~ 484
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UCI(KEPA) : I410-ECN-0101-2013-514-002683769