지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.5
- 수록면
- 379 - 386 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: The aims of this study were to find the risk factor and outcomes of patients with an early recurrence (ER) of a hepatocellular carcinoma (HCC) after liver transplantation (LT) and the actual impact of transarterial chemoembolization (TACE) before LT for a HCC on patient survival and HCC recurrence.
Methods: Ninety-eight cases of adult LT, performed between September 1995 and January 2006, were evaluated. The risk factors and prognosis of patient with a HCC after transplantation for an ER, defined as a recurrence within 6 months of transplantation, and the effects of Pre-LT TACE on the disease-free and overall survival rates, as well as the patterns of recurrence after LT, were studied.
Results: A total of 18 patients (18.4%) experienced a HCC recurrence after LT; 10 and 8 patients had early and late recurrences, respectively. From a univariate analysis, the serum alpha-fetoprotein (P=0.003), tumor size (P=0.003), serosa invasion (P=0.000), tumor grade (P=0.011) and vascular invasion (P=0.014) were statistically significant risk factors for an ER. From a multivariate analysis, the presence of serosa invasion of a HCC was the only independent risk factor for an ER (P=0.009; OR=9.407: 95% CI, 1.764∼50.164). There was no difference in the disease free survival and overall survival rates between the TACE and without TACE groups, but the extrahepatic recurrence rate was higher in the TACE than without TACE group.
Conclusion: Serosa invasion by a HCC is independently associated with an ER of HCC after LT. Pre-LT TACE does not influence the disease-free and overall survivals after LT for a HCC.
Methods: Ninety-eight cases of adult LT, performed between September 1995 and January 2006, were evaluated. The risk factors and prognosis of patient with a HCC after transplantation for an ER, defined as a recurrence within 6 months of transplantation, and the effects of Pre-LT TACE on the disease-free and overall survival rates, as well as the patterns of recurrence after LT, were studied.
Results: A total of 18 patients (18.4%) experienced a HCC recurrence after LT; 10 and 8 patients had early and late recurrences, respectively. From a univariate analysis, the serum alpha-fetoprotein (P=0.003), tumor size (P=0.003), serosa invasion (P=0.000), tumor grade (P=0.011) and vascular invasion (P=0.014) were statistically significant risk factors for an ER. From a multivariate analysis, the presence of serosa invasion of a HCC was the only independent risk factor for an ER (P=0.009; OR=9.407: 95% CI, 1.764∼50.164). There was no difference in the disease free survival and overall survival rates between the TACE and without TACE groups, but the extrahepatic recurrence rate was higher in the TACE than without TACE group.
Conclusion: Serosa invasion by a HCC is independently associated with an ER of HCC after LT. Pre-LT TACE does not influence the disease-free and overall survivals after LT for a HCC.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Iwatsuki S / 1991 / Hepatic resection versus transplantation for hepatocellular carcinoma / Ann Surg 214 : 221 ~ 229
2. [학술지(정기간행물)] - O’Grady JG / 1988 / Liver transplantation for malignant disease / Ann Surg 207 : 373 ~ 379
3. [학술지(정기간행물)] - Bismuth H / 1993 / Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients / Ann Surg 218 : 145 ~ 151
4. [학술지(정기간행물)] - Yokoyama I / 1991 / Clinicopathologic factors affecting patient survival and tumor recurrence after orthotopic liver transplantation for hepatocellular carcinoma / Transplant Proc 23 : 2194 ~ 2196
5. [학술지(정기간행물)] - Mazzaferro V / 1996 / Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis / N Engl J Med 334 : 693 ~ 699
2. [학술지(정기간행물)] - O’Grady JG / 1988 / Liver transplantation for malignant disease / Ann Surg 207 : 373 ~ 379
3. [학술지(정기간행물)] - Bismuth H / 1993 / Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients / Ann Surg 218 : 145 ~ 151
4. [학술지(정기간행물)] - Yokoyama I / 1991 / Clinicopathologic factors affecting patient survival and tumor recurrence after orthotopic liver transplantation for hepatocellular carcinoma / Transplant Proc 23 : 2194 ~ 2196
5. [학술지(정기간행물)] - Mazzaferro V / 1996 / Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis / N Engl J Med 334 : 693 ~ 699
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Long-term outcome of preoperative transarterial chemoembolization and hepatic resection in patients with hepatocellular carcinoma
Clinical and Molecular Hepatology
2010 .01
-
절제 가능한 간세포암에서 수술 전 경동맥화학색전술의 효과
대한내과학회지
2005 .01
-
Clinical usefulness of transarterial chemoembolization response prior to liver transplantation as predictor of optimal timing for living donor liver transplantation
Annals of Surgical Treatment and Research
2018 .08
-
Transcatheter Arterial Chemoembolization Combined with Interferon-α is Safe and Effective for Patients with Hepatocellular Carcinoma after Curative Resection
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
간세포암 치료에서 수술 전 간동맥 화학색전술의 효과
대한내과학회지
2006 .01
-
Prospective Study on the Survival of HCC Patients Treated with Transcatheter Arterial Lipiodol Chemoembolization
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Switching to systemic therapy after locoregional treatment failure: Definition and best timing
Clinical and Molecular Hepatology
2020 .01
-
The role of scheduled second TACE in early-stage hepatocellular carcinoma with complete response to initial TACE
Clinical and Molecular Hepatology
2017 .01
-
Transarterial chemoembolization versus resection for the intermediate stage hepatocellular carcinoma
Clinical and Molecular Hepatology
2016 .01
-
Efficacy of Transarterial Chemoembolization Combined with Radiofrequency Ablation in Treatment of Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Role of Radiofrequency Ablation in Patients with Hepatocellular Carcinoma Who Undergo Prior Transarterial Chemoembolization: Long-Term Outcomes and Predictive Factors
Gut and Liver
2014 .01
-
간세포암 환자의 수술 후 간내 조기 재발에 대한 위험 인자
Annals of Surgical Treatment and Research
2008 .07
-
Factors Affecting Survival after HCC Recurrence in Liver Transplantation
한국간담췌외과학회 학술대회지
2010 .04
-
간문맥혈전을 동반한 간암의 화학색전술 후 장기생존 1예
대한내과학회지
2009 .01
-
Long-term complete response after transcatheter arterial chemoembolization and stereotactic body radiation therapy in a patient with hepatocellular carcinoma at the caudate lobe
Annals of Hepato-Biliary-Pancreatic Surgery
2018 .08
-
Transarterial Chemoembolization Monotherapy in Combination with Radiofrequency Ablation or Percutaneous Ethanol Injection for Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Health-Related Quality of Life of Patients with Intermediate Hepatocellular Carcinoma after Liver Resection or Transcatheter Arterial Chemoembolization
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma
Annals of Surgical Treatment and Research
2018 .03
-
Strategies to reduce HCC recurrence after liver transplantation
대한외과학회 학술대회 초록집
2012 .11
이 논문의 저자 정보
이 논문과 함께 이용한 논문
간세포암 환자에서 간이식 : 국립암센터 100예 보고
김영규
,
이광웅
,
김성훈
외 4명
대한외과학회 학술대회 초록집
2009
.11
간이식 수혜자의 삶의 질 예측모형
김은만
,
김금순
기본간호학회지
2007
.08
절제 가능한 간세포암 환자에서 술전 간동맥색전술과 예후에 대하여
박민호
,
김정철
,
조철균
외 1명
Annals of Hepato-Biliary-Pancreatic Surgery
2001
.06
간세포암 근치적 절제 후 발생한 간외 재발암의 위험인자 분석
이형순
,
최기홍
,
황호경
외 3명
Annals of Hepato-Biliary-Pancreatic Surgery
2010
.12
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-514-002673594