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자료유형
학술저널
저자정보
안혜성 (서울대학교) 장진영 (서울대학교) 이승은 (서울대학교) 양성훈 (서울대학교) 이건욱 (서울대학교) 김선회 (서울대학교)
저널정보
대한외과학회 Annals of Surgical Treatment and Research 대한외과학회지 Vol.72 No.1
발행연도
2007.1
수록면
38 - 45 (8page)

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Purpose: Because of the rarity of primary duodenal adenocarcinomas, the factors affecting the management and survival of patients with this disease remain controversial. This study analyzed the nineteen-years of experience gained at one institution to define the surgical management and outcomes of patients with primary duodenal adenocarcinomas.
Methods: A retrospective review of 77 patients, who underwent surgery for a primary duodenal adenocarcinoma at Seoul National University Hospital, between May 1985 and April 2004, was undertaken. The dermographics symptoms, operative variables, surgical pathology and survival data were analyzed.
Results: A curative resection was performed in 40 patients (51.9%); a pancreaticoduodenectomies and/or resection of other organs, pancreas head resection with a duodenal segmentectomy and a segmental duodenectomy and resection of another organ in 37, 2 and 1, respectively. The remaining 37 patients underwent a palliative resection or bypass. The hospital mortality and complication rates were 2.6% (2 patients) and 42.9% (33 patients), respectively. The overall 5-year survival was 26.8%. The 5-year survival for the curative resection group was 42.7%, whereas that for the palliative surgery group was 0%. In a univariate analysis, nodal metastasis was found to have a significant negative impact on survival after a curative resection (P=0.028). The patients’ age, sex, operative procedure, tumor size, histologic type, differentiation and tumor depth had no influence on survival.
Conclusion: A curative resection is associated with increased survival in patients with a duodenal adenocarcinoma. Following a curative resection, nodal metastasis is an independent prognostic factor. Therefore, the early diagnosis should be sought to achieve a curative resection and increased survival. As a curative resection, a pancreati-coduodenectomy is usually required, and a segmental duodenal resection may be appropriate in selected patients, especially in early duodenum cancers.

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UCI(KEPA) : I410-ECN-0101-2013-514-002674642