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논문 기본 정보

자료유형
학술저널
저자정보
Hye-Rim Lee (충북대학교) Tae-Hee Kim (순천향대학교) Kyung-Chul Choi (충북대학교)
저널정보
한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.28 No.2
발행연도
2012.6
수록면
71 - 76 (6page)

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이 논문의 연구 히스토리 (5)

2012

Human prostate cancer cell growth was stimulated by alkylphenol and phthalate via estrogen receptor and androgen receptor-dependent manners in cellular and xenograft mouse models
Hye-Rim Lee ,  Kyung-Chul Choi 환경독성보건학회 심포지엄 및 학술대회 2012.10 학술대회자료
Treatments of in vitro and in vivo breast cancer models with 4-tert-octylphenol resulted in the strong growth stimulation via an estrogen receptor alpha-mediated signaling pathway
Hye-Rim Lee ,  Kyung-Chul Choi 환경독성보건학회 심포지엄 및 학술대회 2012.10 학술대회자료
A growth of human breast cancer cells was stimulated by octylphenol and triclosan through an estrogen receptor dependent pathway in vitro and in vivo models
Hye-Rim Lee ,  Kyung-Chul Choi 한국실험동물학회 학술발표대회 논문집 2012.08 학술대회자료
Functions and physiological roles of two types of estrogen receptors, ERα and ERβ, identified by estrogen receptor knockout mouse
Hye-Rim Lee ,  Tae-Hee Kim ,  Kyung-Chul Choi Laboratory Animal Research 2012.06 학술저널
Treatment with bisphenol A and phthalate stimulated the growth of human LNCaP prostate cancer cells and induced a cell cycle by upregulating transcriptional levels of c-myc and c-fos
Hye-Rim Lee ,  Kyung-Chul Choi 한국실험동물학회 학술발표대회 논문집 2012.02 학술대회자료

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Estrogens, a class of steroid hormones, regulate the growth, development, and physiology of the human reproductive system. Estrogens also involve in the neuroendocrine, skeletal, adipogenesis, and cardiovascular systems. Estrogen signaling pathways are selectively stimulated or inhibited depending on a balance between the activities of estrogen receptor (ER) α or ERβ in target organs. ERs belong to the steroid hormone superfamily of nuclear receptors, which act as transcription factors after binding to estrogen. The gene expression regulation by ERs is to modulate biological activities, such as reproductive organ development, bone modeling, cardiovascular system functioning, metabolism, and behavior in both females and males. Understanding of the general physiological roles of ERs has been gained when estrogen levels were ablated by ovariectomy and then replenished by treatment with exogenous estrogen. This technique is not sufficient to fully determine the exact function of estrogen signaling in general processes in living tissues. However, a transgenic mouse model has been useful to study gene-specific functions. ERα and ERβ have different biological functions, and knockout and transgenic animal models have distinct phenotypes. Analysis of ERα and ERβ function using knockout mouse models has identified the roles of estrogen signaling in general physiologic processes. Although transgenic mouse models do not always produce consistent results, they are the useful for studying the functions of these genes under specific pathological conditions.
#Estrogen #estrogen receptors #knockout mice

목차

The reproductive system in ER knockout mice
Fertility
Reproductive organs
Mammary gland
Male reproduction
Bone development and maintenance in ER knockout mice
Cardiovascular tissues and metabolism in ER knockout mice
Brain and behavior
Summary
Acknowledgments
References

참고문헌 (54)

참고문헌 신청
Osz J / 2012 / Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors / Proc Natl Acad Sci U S A 109(10):E588~E594 google schola Choi KC / 2003 / The biomarker and endocrine disruptors in mammals / J Reprod Dev 49(5):337~345 google schola Lee HR / 2012 / Treatment with bisphenol A and methoxychlor results in the growth of human breast cancer cells and alteration of the expression of cell cycle-related genes, cyclin D1 and p21, via an estrogen receptor-dependent signaling pathway / Int J Mol Med 29(5):883~890 google schola Swedenborg E / 2009 / Regulation of estrogen receptor beta activity and implications in health and disease / Cell Mol Life Sci 66(24):3873~3894 google schola Hughes ZA / 2009 / Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders / Curr Mol Pharmacol 2(3):215~236 google schola

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