지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 83 - 90 (8page)
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Erectile dysfunction (ED) is a highly prevalent disorder that affects millions of men worldwide. ED is now considered an early manifestation of atherosclerosis, and consequently, a precursor of systemic vascular disease. This study was designed to investigate the effects of male silkworm pupa powder (SWP) on the levels of nitric oxide synthase (NOS) expression, nitrite, and glutathione (GSH); lipid peroxidation; libido; and erectile response of the corpus cavernosum of the rat penis. We induced ED in the study animals by oral administration of 20% ethanol over 8 weeks. The SWP-treated male rats were divided into 3 groups that were orally administered 200, 400, and 800 ㎎/㎏. The libido of the SWP-administered male rats was higher than that of the ethanol control group. In addition, the erectile response of the corpus cavernosum was restored in males on SWP administration, to a level similar to that of the normal group without ED. The testosterone concentration did not increase significantly. The lipid peroxidation in the corpus cavernosum of the male rats administered SWP decreased significantly. In contrast, compared to the ethanol group, SWP-administered male rats showed increased GSH levels in the corpus cavernosum. The level of nitrite and NOS expression in the corpus cavernosum of SWP-administered male rats increased significantly. These results indicated that SWP effectively restored ethanol-induced ED in male rats.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (26)
참고문헌 신청
Maas R / 2002 / The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function / Vasc Med 7(3):213~225
Benet AE / 1995 / The epidemiology of erectile dysfunction / Urol Clin North Am 22(4):699~709
Cheng JY / 2007 / Alcohol consumption and erectile dysfunction: meta-analysis of population-based studies / Int J Impot Res 19(4):343~352
Christ GJ / 1995 / The penis as a vascular organ. The importance of corporal smooth muscle tone in the control of erection / Urol Clin North Am 22(4):727~745
Hedlund H / 1985 / Contraction and relaxation induced by some prostanoids in isolated human penile erectile tissue and cavernous artery / J Urol 134(6):1245~1250
Benet AE / 1995 / The epidemiology of erectile dysfunction / Urol Clin North Am 22(4):699~709
Cheng JY / 2007 / Alcohol consumption and erectile dysfunction: meta-analysis of population-based studies / Int J Impot Res 19(4):343~352
Christ GJ / 1995 / The penis as a vascular organ. The importance of corporal smooth muscle tone in the control of erection / Urol Clin North Am 22(4):727~745
Hedlund H / 1985 / Contraction and relaxation induced by some prostanoids in isolated human penile erectile tissue and cavernous artery / J Urol 134(6):1245~1250
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UCI(KEPA) : I410-ECN-0101-2013-510-002637101