지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 147 - 150 (4page)
이용수
이 논문의 연구 히스토리 (2)
2012
Differential expression pattern of Tmie protein in postnatal stages of C57BL/6J mice
Sanka
,
apandian Ka
,
uppasamy
외 4명
한국실험동물학회 학술발표대회 논문집
2012.08
학술대회자료
Expression of deafness protein Tmie in postnatal developmental stages of C57BL/6J mice
Sanka
,
apandian Ka
,
uppasamy
외 4명
Laboratory Animal Research
2012.06
학술저널
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초록· 키워드
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Loss-of function mutations in the transmembrane inner ear expressed (Tmie/TMIE) gene have been shown to cause deafness in mice and humans (DFNB6). Previous studies report that the circling mouse can be an animal model for DFNB6. However, the expression pattern of Tmie protein in postnatal developmental stages has not been clearly revealed. In this study we tried to investigate the expression of Tmie protein in the liver, spleen, kidney, and lung, as well as in the cochlea. We examined various tissue samples from five different age groups of C57BL/6J animals. Using western blotting analysis, the expression of Tmie protein in these organs has been identified. The results show that Tmie protein expression in the cochlea has been increased in postnatal developmental stages, indicating that Tmie plays an important role in not only the development and also in the function of the cochlea. The expression pattern of Tmie in adult mouse organs such as the liver, spleen, kidney, and spleen significantly vary in adult rats. The order of Tmie expression level in mice (63 days after birth) was spleen, liver, lung, cochlea, and kidney, whereas in the adult rat it was liver, cochlea, lung, spleen, and kidney.
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참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Morton NE / 1991 / Genetic epidemiology of hearing impairment / Ann N Y Acad Sci 630 : 16 ~ 31
2. [학술지(정기간행물)] - Mehl AL / 1998 / Newborn hearing screening: the great omission / Pediatrics 101 (1) : E4 ~
3. [학술지(정기간행물)] - Petit C / 2001 / Molecular genetics of hearing loss / Annu Rev Genet 35 : 589 ~ 646
4. [학술지(정기간행물)] - Resendes BL / 2001 / At the speed of sound: gene discovery in the auditory system / Am J Hum Genet 69 (5) : 923 ~ 935
5. [학술지(정기간행물)] - Keats BJ / 1999 / Genomics and hearing impairment / Genome Res 9 (1) : 7 ~ 16
2. [학술지(정기간행물)] - Mehl AL / 1998 / Newborn hearing screening: the great omission / Pediatrics 101 (1) : E4 ~
3. [학술지(정기간행물)] - Petit C / 2001 / Molecular genetics of hearing loss / Annu Rev Genet 35 : 589 ~ 646
4. [학술지(정기간행물)] - Resendes BL / 2001 / At the speed of sound: gene discovery in the auditory system / Am J Hum Genet 69 (5) : 923 ~ 935
5. [학술지(정기간행물)] - Keats BJ / 1999 / Genomics and hearing impairment / Genome Res 9 (1) : 7 ~ 16
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UCI(KEPA) : I410-ECN-0101-2013-510-002637196