지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.8
- 수록면
- 151 - 157 (7page)
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초록· 키워드
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In this research, the genotoxic effect of Bupleuri Radix (BR), the dried roots of Bupleurum falcatum Linne has been traditionally used as anti-inflammatory agent, was evaluated using the mouse micronucleus test. BR aqueous extract(yield = 16.52%) was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2,000, 1,000 and 500 mg/kg. Cyclophosphamide (CPA) 70 mg/kg was used as a known genotoxic agent in a positive control. The appearance of a micronucleus (MN) in polychromatic erythrocyte (PCE) is used as an index for genotoxic potential, and PCE ratio is used as an index of cytotoxicity. Although significant (p<0.01) increase of the number of PCE with one or more nuclei (MNPCE) was detected in CPA treated groups, no significant increases of MNPCE numbers were observed in all three different dosages of BR extracts treated mice with over 0.30 of the individual polychromatic erythrocyte ratio in all mice used in this study. The results obtained indicated that BR extract shows no genotoxicity effects up to 2,000 mg/kg dosing levels the limit dosage in rodents.
목차
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
ACKNOWLEDGMENT
REFERENCES
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - 이지은 / 2003 / 반하의 4주 반복투여독성 평가 / Laboratory Animal Research 19 (3) : 127 ~ 141
2. [학술지(정기간행물)] - In-Kwon Chung / 2011 / Micronucleus Test of Picrorrhiza Rhizoma Aqueous Extract in Bone Marrow Cells of Male ICR Mice / 한국독성학회지 27 (2) : 119 ~ 123
3. [학술지(정기간행물)] - Renner HW / 1990 / In vivo effects of single or combined dietary antimutagens on mutageninduced chromosomal aberrations / Mutat Res 244 (2) : 185 ~ 188
4. [기타자료] - Korea Food and Drug Administration / 2009 / Testing Guidelines for Safety Evaluation of Drugs / 2009-116
5. [학술지(정기간행물)] - Kalantari H / 2007 / The genotoxicity study of garlic and pasipy herbal drops by peripheral blood micronucleus test / Acta Physiol Hung 94 (3) : 261 ~ 266
2. [학술지(정기간행물)] - In-Kwon Chung / 2011 / Micronucleus Test of Picrorrhiza Rhizoma Aqueous Extract in Bone Marrow Cells of Male ICR Mice / 한국독성학회지 27 (2) : 119 ~ 123
3. [학술지(정기간행물)] - Renner HW / 1990 / In vivo effects of single or combined dietary antimutagens on mutageninduced chromosomal aberrations / Mutat Res 244 (2) : 185 ~ 188
4. [기타자료] - Korea Food and Drug Administration / 2009 / Testing Guidelines for Safety Evaluation of Drugs / 2009-116
5. [학술지(정기간행물)] - Kalantari H / 2007 / The genotoxicity study of garlic and pasipy herbal drops by peripheral blood micronucleus test / Acta Physiol Hung 94 (3) : 261 ~ 266
이 논문의 저자 정보
이 논문과 함께 이용한 논문
시호(Bupleuri Radix)분말이 과산화지질을 급여한 흰쥐의 혈장 및 간장지질구성과 항산화능에 미치는 영향
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