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논문 기본 정보

자료유형
학술저널
저자정보
Woo-Hyun Cheon (Daegu Haany University) In-Kwon Chung (Daegu Haany University) Su-Jin Kang (Daegu Haany University) Sae-Kwang Ku (Daegu Haany University) Young-Joon Lee (Daegu Haany University)
저널정보
한국한의학연구원 한국한의학연구원 논문집 한국한의학연구원논문집 제18권 제2호
발행연도
2012.8
수록면
151 - 157 (7page)

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초록· 키워드

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In this research, the genotoxic effect of Bupleuri Radix (BR), the dried roots of Bupleurum falcatum Linne has been traditionally used as anti-inflammatory agent, was evaluated using the mouse micronucleus test. BR aqueous extract(yield = 16.52%) was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2,000, 1,000 and 500 mg/kg. Cyclophosphamide (CPA) 70 mg/kg was used as a known genotoxic agent in a positive control. The appearance of a micronucleus (MN) in polychromatic erythrocyte (PCE) is used as an index for genotoxic potential, and PCE ratio is used as an index of cytotoxicity. Although significant (p<0.01) increase of the number of PCE with one or more nuclei (MNPCE) was detected in CPA treated groups, no significant increases of MNPCE numbers were observed in all three different dosages of BR extracts treated mice with over 0.30 of the individual polychromatic erythrocyte ratio in all mice used in this study. The results obtained indicated that BR extract shows no genotoxicity effects up to 2,000 mg/kg dosing levels the limit dosage in rodents.

목차

Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
ACKNOWLEDGMENT
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2013-519-003189103