지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 47 - 51 (5page)
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초록· 키워드
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Purpose: This study evaluated the role of stereotactic body radiotherapy (SBRT) for oligometastases from colorectal cancer(CRC).
Materials and results: Between 2003 and 2009, total of 41 patients with 50 lesions confined to one organ from colorectal cancer and treated with high dose SBRT above 45 Gy or more were involved in. The metastatic organs were the lymph node (18 patients), lung (12) and liver (11). SBRT doses ranged from 45 to 60 Gy in 3 fractions (median 48 Gy). The 3-year local control and overall survival rates were 64% and 60%, and the respective 5-year rates were 57% and 38%. Cumulative gross tumor volume and SBRT dose were statistically significant prognostic factors for local control. The grade 3 or 4 intestinal complications occurred in 3 patients(7%) to receive 48 or 51 Gy.
Conclusions: High dose SBRT °√ 45Gy for oligometastases from CRC showed comparable result with surgical series. For improvement of local control, higher dose °√ 48Gy is recommend when possible. However, considering severe complications above grade 3 occurred in °√ 48 Gy, further study will be required to define the optimal constraint for normal tissue such as intestine.
Materials and results: Between 2003 and 2009, total of 41 patients with 50 lesions confined to one organ from colorectal cancer and treated with high dose SBRT above 45 Gy or more were involved in. The metastatic organs were the lymph node (18 patients), lung (12) and liver (11). SBRT doses ranged from 45 to 60 Gy in 3 fractions (median 48 Gy). The 3-year local control and overall survival rates were 64% and 60%, and the respective 5-year rates were 57% and 38%. Cumulative gross tumor volume and SBRT dose were statistically significant prognostic factors for local control. The grade 3 or 4 intestinal complications occurred in 3 patients(7%) to receive 48 or 51 Gy.
Conclusions: High dose SBRT °√ 45Gy for oligometastases from CRC showed comparable result with surgical series. For improvement of local control, higher dose °√ 48Gy is recommend when possible. However, considering severe complications above grade 3 occurred in °√ 48 Gy, further study will be required to define the optimal constraint for normal tissue such as intestine.
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Introduction
Materials & Results
Discussion & conclusions
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UCI(KEPA) : I410-ECN-0101-2014-513-001297066