지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 90 - 100 (11page)
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Purpose: In spite of the recent improved results of hepatectomy for huge hepatocellular carcinomas (HCC), the prognosis of patients with huge HCCs is still poor compared to that of patients with small HCCs. This study was performed to compare the results of hepatectomy between patients with huge HCCs and those with small HCCs, to identify the prognostic factors in patients with huge HCCs, and to determine the preoperative selection criteria.
Methods: We retrospectively analyzed 51 patients who underwent hepatectomy, between July 1994 and February 2009 at Dankook University Hospital. Patients with HCC≥10 cm were classified in large (L) group and others were classified in small (S) group. The clinicopathological features, operative procedures, and postoperative outcome were compared between both groups and various prognostic factors were investigated in group L.
Results: Eleven patients were classified in group L. Tumor size, vascular invasion, and tumor stage were higher in group L. Postoperative morbidity was higher in group L, but mortality was not different between the groups. Disease-free survivals were significantly lower in group L than in group S (36.4%, and 24.2% vs. 72.0%, and 44.0% for 1- and 3-year), but overall survival rates were similar in both groups (45.5%, and 15.2% in group L vs. 60.3%, and 41.3% in group S for 3- and 5-year). Presence of satellite nodules was the only prognostic factor in multivariate analysis after surgery for huge HCC.
Conclusion: Regardless of tumor size, huge HCCs deserve consideration for surgery in patients with preserved liver function. Furthermore, the effect of surgery could be maximized with appropriate selection criteria, such as huge HCC without satellite nodules.
Methods: We retrospectively analyzed 51 patients who underwent hepatectomy, between July 1994 and February 2009 at Dankook University Hospital. Patients with HCC≥10 cm were classified in large (L) group and others were classified in small (S) group. The clinicopathological features, operative procedures, and postoperative outcome were compared between both groups and various prognostic factors were investigated in group L.
Results: Eleven patients were classified in group L. Tumor size, vascular invasion, and tumor stage were higher in group L. Postoperative morbidity was higher in group L, but mortality was not different between the groups. Disease-free survivals were significantly lower in group L than in group S (36.4%, and 24.2% vs. 72.0%, and 44.0% for 1- and 3-year), but overall survival rates were similar in both groups (45.5%, and 15.2% in group L vs. 60.3%, and 41.3% in group S for 3- and 5-year). Presence of satellite nodules was the only prognostic factor in multivariate analysis after surgery for huge HCC.
Conclusion: Regardless of tumor size, huge HCCs deserve consideration for surgery in patients with preserved liver function. Furthermore, the effect of surgery could be maximized with appropriate selection criteria, such as huge HCC without satellite nodules.
목차
Introduction
Methods
Results
Discussion
Conclusion
References
참고문헌 (30)
참고문헌 신청
1. [보고서] - Korea Central Cancer Registry / 2010 / 2008 Cancer Statistics in Korea
2. [학술지(정기간행물)] - Poon RT / 2002 / Selection criteria for hepatic resection in patients with large hepatocellular carcinoma larger than 10 cm in diameter / J Am Coll Surg 194 : 592 ~ 602
3. [학술지(정기간행물)] - Hanazaki K / 2002 / Hepatic resection for hepatocellular carcinoma in diameter of ＞or=10 cm / Hepatogastroenterology 49 : 518 ~ 523
4. [학술지(정기간행물)] - Zhou XD / 2003 / Surgery for large primary liver cancer more than 10 cm in diameter / J Cancer Res Clin Oncol 129 : 543 ~ 548
5. [학술지(정기간행물)] - Nagano Y / 2005 / Efficacy of hepatic resection for hepatocellular carcinomas larger than 10 cm / World J Surg 29 : 66 ~ 71
2. [학술지(정기간행물)] - Poon RT / 2002 / Selection criteria for hepatic resection in patients with large hepatocellular carcinoma larger than 10 cm in diameter / J Am Coll Surg 194 : 592 ~ 602
3. [학술지(정기간행물)] - Hanazaki K / 2002 / Hepatic resection for hepatocellular carcinoma in diameter of ＞or=10 cm / Hepatogastroenterology 49 : 518 ~ 523
4. [학술지(정기간행물)] - Zhou XD / 2003 / Surgery for large primary liver cancer more than 10 cm in diameter / J Cancer Res Clin Oncol 129 : 543 ~ 548
5. [학술지(정기간행물)] - Nagano Y / 2005 / Efficacy of hepatic resection for hepatocellular carcinomas larger than 10 cm / World J Surg 29 : 66 ~ 71
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UCI(KEPA) : I410-ECN-0101-2014-514-001274473