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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 254 - 261 (8page)
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Purpose: We wanted to evaluate the clinical effectiveness of intraoperative radiation therapy (IORT) in combination with external beam radiation therapy (EBRT) for treating unresectable or metastatic pancreatic cancer.
Methods: From August 1993 to July 2007, 28 patients with unresectable or metastatic pancreatic cancer received IORT (median: 20 Gy) combined with or without EBRT (median: 50.4 Gy). Eighteen patients were treated with IORT followed by EBRT, and 10 patients were treated by IORT alone. Eighteen patients underwent explolaparotomy and 10 patients underwent bypass surgery.
Results: The 1-year overall survival rate (OS) and the median survival time of all 28 patients were 21.4% and 7.5 months, respectively. The 1-year OS and median survival time for the clinical stage III patients were 33.3% and 10.2 months, respectively, and they were 7.7% and 5.1 months for the clinical stage IV patients, respectively (p=0.007). Univariate analyses revealed that the stage, chemotherapy and tumor volume were the significant prognostic factors for OS. The patients treated with IORT combined with EBRT had a more favorable 1-year local control rate than that of those patients treated with IORT alone (88.9% vs. 50.0, respectively, p=0.009). But the significant improvement in local control did not translate into a survival benefit. The addition of EBRT was an independent prognostic factor for improving the local control rate. The operative mortality was 0%.
Conclusion: IORT combined with EBRT is considered to be effective in achieving local control and palliation for patients with unresectable or metastatic pancreatic cancer. Further, IORT seems to be safe and it does not increase the mortality or the incidence of surgical wound infection.
Methods: From August 1993 to July 2007, 28 patients with unresectable or metastatic pancreatic cancer received IORT (median: 20 Gy) combined with or without EBRT (median: 50.4 Gy). Eighteen patients were treated with IORT followed by EBRT, and 10 patients were treated by IORT alone. Eighteen patients underwent explolaparotomy and 10 patients underwent bypass surgery.
Results: The 1-year overall survival rate (OS) and the median survival time of all 28 patients were 21.4% and 7.5 months, respectively. The 1-year OS and median survival time for the clinical stage III patients were 33.3% and 10.2 months, respectively, and they were 7.7% and 5.1 months for the clinical stage IV patients, respectively (p=0.007). Univariate analyses revealed that the stage, chemotherapy and tumor volume were the significant prognostic factors for OS. The patients treated with IORT combined with EBRT had a more favorable 1-year local control rate than that of those patients treated with IORT alone (88.9% vs. 50.0, respectively, p=0.009). But the significant improvement in local control did not translate into a survival benefit. The addition of EBRT was an independent prognostic factor for improving the local control rate. The operative mortality was 0%.
Conclusion: IORT combined with EBRT is considered to be effective in achieving local control and palliation for patients with unresectable or metastatic pancreatic cancer. Further, IORT seems to be safe and it does not increase the mortality or the incidence of surgical wound infection.
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고찰
결론
참고문헌
참고문헌 (23)
참고문헌 신청
1. [기타자료] - Ministry for Heath, Welfare and Family Affairs / 2009 / Annual Report of cancer incidence (2007) and survival (1993-2007) in Korea
2. [학술지(정기간행물)] - Bilimoria KY / 2007 / Validation of the 6th edition AJCC Pancreatic Cancer Staging System: report from the National Cancer Database / Cancer 110 : 738 ~ 744
3. [단행본] - Evans D / 2001 / Cancer of the pancreas. 6th ed / Lippincott Williams & Wilkins
4. [단행본] - Willett CG / 2009 / Cancer of the Pancreas. In: Principles and Practice of Radiation oncology. 5th ed / Lippincott Co : 1336 ~ 1346
5. [학술지(정기간행물)] - Kruse EJ / 2010 / Palliation in pancreatic cancer / Surg Clin North Am 90 : 355 ~ 364
2. [학술지(정기간행물)] - Bilimoria KY / 2007 / Validation of the 6th edition AJCC Pancreatic Cancer Staging System: report from the National Cancer Database / Cancer 110 : 738 ~ 744
3. [단행본] - Evans D / 2001 / Cancer of the pancreas. 6th ed / Lippincott Williams & Wilkins
4. [단행본] - Willett CG / 2009 / Cancer of the Pancreas. In: Principles and Practice of Radiation oncology. 5th ed / Lippincott Co : 1336 ~ 1346
5. [학술지(정기간행물)] - Kruse EJ / 2010 / Palliation in pancreatic cancer / Surg Clin North Am 90 : 355 ~ 364
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UCI(KEPA) : I410-ECN-0101-2014-514-001267734