A Case of Liver Metastasis of Gastrointestinal Stromal Tumor That Was Resected after Treatment with Imatinib Mesylate and Sunitinib

Gum O Jung; Kwon Mook Chae; Dong Eun Park; Hyeok Shim; Sang Hyun Park; Ki Jung Yun

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자료유형: 학술저널

저자정보: Gum O Jung (Wonkwang University Hospital, Wonkwang University College of Medicine) Kwon Mook Chae (Wonkwang University Hospital, Wonkwang University College of Medicine) Dong Eun Park (Wonkwang University Hospital, Wonkwang University College of Medicine) Hyeok Shim (Wonkwang University Hospital, Wonkwang University College of Medicine) Sang Hyun Park (Wonkwang University Hospital, Wonkwang University College of Medicine) Ki Jung Yun (Wonkwang University Hospital, Wonkwang University College of Medicine)

저널정보: 한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제14권 제4호

발행연도: 2010.12

수록면: 262 - 266 (5page)

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A 65-year old man underwent wedge resection for a gastrointestinal stromal tumor (GIST) of the gastric fundus in 1997. In 2003, the abdominal CT and sono-guided biopsy revealed he had a large GIST liver metastasis. He underwent treatment with 400 mg/day of imatinib mesylate. As a result, the liver metastasis markedly decreased in size. However, focal progression of the liver metastasis was observed on the follow up CT, so we increased the imatinib from 400 mg/day to 800 mg/day. We then performed extended left hepatectomy. We report here on a patient who presented with an isolated metastatic GIST to the liver, and the patient was successfully treated with imatinib therapy and hemihepatectomy.

#Gastrointestinal stromal tumors #Imatinib mesylate #Liver metastasis #Liver resection

참고문헌 (10)

참고문헌 신청

1. [학술지(정기간행물)] - Blanke CD / 2008 / Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT / J Clin Oncol 26 : 620 ~ 625

2. [학술지(정기간행물)] - Hirota S / 1998 / Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors / Science 279 : 577 ~ 580

3. [학술지(정기간행물)] - Heinrich MC / 2000 / Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor / Blood 96 : 925 ~ 932

4. [학술지(정기간행물)] - Miettinen M / 2006 / Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis / Arch Pathol Lab Med 130 : 1466 ~ 1478

5. [학술지(정기간행물)] - DeMatteo RP / 2000 / Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival / Ann Surg 231 : 51 ~ 58

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