지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 64 - 74 (11page)
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Purpose: The aim of the present study was to determine proper treatment strategies to improve the outcome of patients with gallbladder cancer by an analysis of multiple factors affecting tumor recurrence and patient survival.
Methods: Between January 1991 and April 2006, surgery with curative intent was performed on 120 patients with gallbladder cancer. Of 120 cases, 35 patients had findings that precluded any further intervention, and the remaining 85 patients underwent curative resections that included a simple cholecystectomy in 43 cases, a radical cholecystectomy in 32 cases and an extended cholecystectomy in 10 cases. Clinicopathogical data was analyzed.
Results: The presence of jaundice at presentation, gross morphology of the tumor, tumor cell differentiation, presence of a lymph node metastasis, lymphatic invasion and direct invasion to other contagious organ(s) and achievement of a tumor-free resection margin were associated with survival. For stage I gallbladder cancer, in only T2 lesions, patients that undergone a simple cholecystectomy had double the rate of recurrence as compared to patients that undergone a radical cholecystectomy (12.5% versus 26.1%; p = .119). For stage II gallbladder cancer, survival and disease-free survival for patients that undergone a radical cholecystectomy were improved as compared to patients that undergone a simple cholecystectomy; survival and disease-free survival was poor for patients that had undergone an extended cholecystectomy, especially in patients that had bile duct invasion (4/5; 80%). For stage III/IV gallbladder cancer, all patients (n = 6) underwent an extended cholecystectomy and half of the patients survived longer than one year.
Conclusion: Radical cholecystectomy could be a standard procedure for gallbladder cancer in addition to just stage II cancer. An aggressive approach including resecting contagious organ(s) in locally advanced gallbladder cancer could provide a survival benefit without an increase in complications.
Methods: Between January 1991 and April 2006, surgery with curative intent was performed on 120 patients with gallbladder cancer. Of 120 cases, 35 patients had findings that precluded any further intervention, and the remaining 85 patients underwent curative resections that included a simple cholecystectomy in 43 cases, a radical cholecystectomy in 32 cases and an extended cholecystectomy in 10 cases. Clinicopathogical data was analyzed.
Results: The presence of jaundice at presentation, gross morphology of the tumor, tumor cell differentiation, presence of a lymph node metastasis, lymphatic invasion and direct invasion to other contagious organ(s) and achievement of a tumor-free resection margin were associated with survival. For stage I gallbladder cancer, in only T2 lesions, patients that undergone a simple cholecystectomy had double the rate of recurrence as compared to patients that undergone a radical cholecystectomy (12.5% versus 26.1%; p = .119). For stage II gallbladder cancer, survival and disease-free survival for patients that undergone a radical cholecystectomy were improved as compared to patients that undergone a simple cholecystectomy; survival and disease-free survival was poor for patients that had undergone an extended cholecystectomy, especially in patients that had bile duct invasion (4/5; 80%). For stage III/IV gallbladder cancer, all patients (n = 6) underwent an extended cholecystectomy and half of the patients survived longer than one year.
Conclusion: Radical cholecystectomy could be a standard procedure for gallbladder cancer in addition to just stage II cancer. An aggressive approach including resecting contagious organ(s) in locally advanced gallbladder cancer could provide a survival benefit without an increase in complications.
목차
서론
방법
결과
고찰
결론
참고문헌
참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Foster JM / 2007 / Gallbladder cancer: Defining the indications for primary radical resection and radical re-resection / Ann Surg Oncol 14 : 833 ~ 840
2. [학술지(정기간행물)] - Yagi H / 2006 / Retrospective analysis of outcome in 63 gallbladder carcinoma patients after radical resection / J Hepatobiliary Pancreat Surg 13 : 530 ~ 536
3. [학술지(정기간행물)] - Shih SP / 2007 / Gallbladder cancer: the role of laparoscopy and radical resection / Ann Surg 245 : 893 ~ 901
4. [학술지(정기간행물)] - Ito H / 2004 / Treatment outcomes associated with surgery for gallbladder cancer: a 20-year experience / J Gastrointest Surg 8 : 183 ~ 190
5. [학술지(정기간행물)] - Dixon E / 2005 / An aggressive surgical approach leads to improved survival in patients with gallbladder cancer: a 12-year study at a North American Center / Ann Surg 241 : 385 ~ 394
2. [학술지(정기간행물)] - Yagi H / 2006 / Retrospective analysis of outcome in 63 gallbladder carcinoma patients after radical resection / J Hepatobiliary Pancreat Surg 13 : 530 ~ 536
3. [학술지(정기간행물)] - Shih SP / 2007 / Gallbladder cancer: the role of laparoscopy and radical resection / Ann Surg 245 : 893 ~ 901
4. [학술지(정기간행물)] - Ito H / 2004 / Treatment outcomes associated with surgery for gallbladder cancer: a 20-year experience / J Gastrointest Surg 8 : 183 ~ 190
5. [학술지(정기간행물)] - Dixon E / 2005 / An aggressive surgical approach leads to improved survival in patients with gallbladder cancer: a 12-year study at a North American Center / Ann Surg 241 : 385 ~ 394
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UCI(KEPA) : I410-ECN-0101-2014-514-001248280