지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.10
- 수록면
- 375 - 382 (8page)
이용수
초록· 키워드
오류제보하기
Ginsenoside Rp1 (G-Rp1) is a saponin derivate that provides anti-metastatic activities through inhibition of the NF-κB pathway. In this study, we examined the effects of G-Rp1 on regulatory T cell (Treg) activation. After treatment of splenocytes with G-Rp1, Tregs exhibited upregulation of IL-10 expression, and along with dendritic cells (DCs), these Tregs showed increased cell number compared to other cell populations. The effect of G-Rp1 on Treg number was augmented in the presence of lipopolysaccharide (LPS), which mimics pathological changes that occur during infl ammation. However, depletion of DCs prevented the increase in Treg number in the presence of G-Rp1 and/or LPS. In addition, G-Rp1 promoted the differentiation of the memory types of CD4+Foxp3+CD62Llow Tregs rather than the generation of new Tregs. In vivo experiments also demonstrated that Tregs and DCs from mice that were fed G-Rp1 for 7 d and then injected with LPS exhibited increased activation compared with those from mice that were injected with LPS alone. Expression of TGF-β and CTLA4 in Tregs was increased, and upregulation of IL-2 and CD80/CD86 expression by DCs affected the suppressive function of Tregs through IL-2 receptors and CTLA4. These data demonstrate that G-Rp1 exerts anti-infl ammatory effects by activating Tregs in vitro and in vivo.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Wang W / 2007 / In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng / Cancer Chemother Pharmacol 59 : 589 ~ 601
2. [학술지(정기간행물)] - Tode T / 1993 / Inhibitory effects by oral administration of ginsenoside Rh2 on the growth of human ovarian cancer cells in nude mice / J Cancer Res Clin Oncol 120 : 24 ~ 26
3. [학술지(정기간행물)] - Hyun-Sook Kim / 2004 / Effects of Ginsenosides Rg3 and Rh2 on the Proliferation of Prostate Cancer Cells / Archives of Pharmacal Research 27 (4) : 429 ~ 435
4. [학술지(정기간행물)] - Oh M / 1999 / Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells / Int J Oncol 14 : 869 ~ 875
5. [학술지(정기간행물)] - Ji Yon Shin / 2012 / Anti-Cancer Effect of Ginsenoside F2 against Glioblastoma Multiforme in Xenograft Model in SD Rats / Journal of Ginseng Research 36 (1) : 86 ~ 92
2. [학술지(정기간행물)] - Tode T / 1993 / Inhibitory effects by oral administration of ginsenoside Rh2 on the growth of human ovarian cancer cells in nude mice / J Cancer Res Clin Oncol 120 : 24 ~ 26
3. [학술지(정기간행물)] - Hyun-Sook Kim / 2004 / Effects of Ginsenosides Rg3 and Rh2 on the Proliferation of Prostate Cancer Cells / Archives of Pharmacal Research 27 (4) : 429 ~ 435
4. [학술지(정기간행물)] - Oh M / 1999 / Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells / Int J Oncol 14 : 869 ~ 875
5. [학술지(정기간행물)] - Ji Yon Shin / 2012 / Anti-Cancer Effect of Ginsenoside F2 against Glioblastoma Multiforme in Xenograft Model in SD Rats / Journal of Ginseng Research 36 (1) : 86 ~ 92
이 논문의 저자 정보
이 논문과 함께 이용한 논문
항암 면역 증강 작용이 있는 인삼 다당체에 의한 cytokine mRNA의 발현 ( The Pattern of Cytokine mRNA Expression Induced by Polysaccharide from Panax ginseng C. A. Meyer )
김기환
,
이인란
,
정인성
외 2명
Journal of Ginseng Research
1998
.12
인삼 사포닌이 인간면역계 사이토카인 유전자의 발현에 미치는 영향 ( Effects of Ginseng Saponin on the Cytokine Gene Expression in Human Immune System )
박종욱
,
한인숙
,
서성일
외 4명
Journal of Ginseng Research
1996
.04
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-524-001184421