Objectives:The purpose of this study was to investigate the effects of stress and mood symptoms on nicotine dependence in soldiers. Methods:The participants were 131 military soldiers. The data was collected from military soldiers by using selfreport questionnaire. The instrument used were Fagerstrom’s Test for Nicotine Dependence(FTND), Brief Encounter Psychosocial Instrument-Korean version(BEPSI-K), Center for Epidemiologic Studies Depression Scale(CES-D), Bipolar Spectrum Diagnostic Scale(BSDS). We tried to find the difference of the variables according to smoking status and nicotine dependence determined by FTND score. We analyzed the correlation of FTND score, BEPSI-K score, CES-D score and BSDS score and investigated the independent effect that each variable has upon moderate to severe nicotine dependence using multivariate logistic regression. Results:Among the total 131 military soldiers, 57 subjects smoke(43.5%). Comparing to three groups according to FTND score, moderate to severe groups were higher than another groups in CES-D score(5.62±5.73 vs. 4.19± 4.29 vs. 8.84±6.69, p=0.01). FTND score positively correlated to BEPSI-K score(r=0.17, p=0.04) and CES-D score(r=0.23, p=0.01). As a results of analyzing the independent effect that each variables has upon moderate to severe nicotine dependence, depression is only risk factor for moderate to severe nicotine dependence(O.R=1.1, p=0.01, 95% C.I=1.03-1.18). Conclusions:Nicotine dependence is associated with stress and depression and especially, depression is a risk factor for moderate to severe nicotine dependence in soldiers.