지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 194 - 200 (7page)
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초록· 키워드
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Background and Aims：Relatively few studies have explored the quality of life(QOL) in mild cognitive impairment (MCI) and Alzheimer’s disease(AD). This study aimed to compare the QOL in MCI with that in AD.
Methods：24 normal controls, 29 mild MCI patients, 20 AD patients, and their caregivers participated. QOL was assessed using the Korean version of QOL-AD(KQOL-AD). Korean version-Mini Mental State Examination(K-MMSE), Activities of Daily Living(ADL), Clinical Dementia Rating(CDR), and Neuropsychiatric Inventory(NPI) were also used to assess the participants.
Results：Both patient and caregiver-reported QOL scores of AD group were lower than those of MCI and control groups. However, there were no significant differences among the three groups in QOL(p=0.069, p=0.058). Patientreported QOL scores of all participants showed were significant negative correlations with ADL scores and NPI scores, but not with K-MMSE scores(r=-0.316, p=0.009 ; r=-0.349, p=0.010 ; and r=0.094, p=0.430). Caregiverreported QOL scores of all participants showed significant negative correlations with ADL scores and NPI scores, but not with K-MMSE scores(r=-0.369, p=0.015 ; r=-0.413, p=0.007 ; and r=0.147, p=0.341).
Conclusion：Both patient-reported and caregiver-reported QOL scores of AD patients were not significantly different from those of MCI patients and normal controls. NPI and ADL scores were negatively associated with QOL, while K-MMSE scores were not. Thus, therapeutic strategies for behavioral and psychological symptoms of MCI and AD will be need to improve patient QOL.
Methods：24 normal controls, 29 mild MCI patients, 20 AD patients, and their caregivers participated. QOL was assessed using the Korean version of QOL-AD(KQOL-AD). Korean version-Mini Mental State Examination(K-MMSE), Activities of Daily Living(ADL), Clinical Dementia Rating(CDR), and Neuropsychiatric Inventory(NPI) were also used to assess the participants.
Results：Both patient and caregiver-reported QOL scores of AD group were lower than those of MCI and control groups. However, there were no significant differences among the three groups in QOL(p=0.069, p=0.058). Patientreported QOL scores of all participants showed were significant negative correlations with ADL scores and NPI scores, but not with K-MMSE scores(r=-0.316, p=0.009 ; r=-0.349, p=0.010 ; and r=0.094, p=0.430). Caregiverreported QOL scores of all participants showed significant negative correlations with ADL scores and NPI scores, but not with K-MMSE scores(r=-0.369, p=0.015 ; r=-0.413, p=0.007 ; and r=0.147, p=0.341).
Conclusion：Both patient-reported and caregiver-reported QOL scores of AD patients were not significantly different from those of MCI patients and normal controls. NPI and ADL scores were negatively associated with QOL, while K-MMSE scores were not. Thus, therapeutic strategies for behavioral and psychological symptoms of MCI and AD will be need to improve patient QOL.
목차
서론
대상 및 방법
결과
고찰
참고문헌
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Mega MS / 1996 / The spectrum of behavioral changes in Alzheimer’s disease / Neurology 46 : 130 ~ 135
2. [학술지(정기간행물)] - Levy ML / 1996 / Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer’s disease / Am J Psychiatry 153 : 1438 ~ 1443
4. [단행본] - World Health Organization / 1995 / World Health Organization Quality of Life-100 / World Health Organization, Division of Mental Health
5. [학술지(정기간행물)] - 홍석경 / 2002 / 파킨슨병 환자의 삶의 질 / 대한신경과학회지 20 (3) : 227 ~ 233
6. [단행본] - Logsdon RG / 2000 / Quality of life in Alzheimer’s disease: patient and caregiver reports, in Assessing Quality of Life in Alzheimer’s Disease / Spring Publishing Company : 17 ~ 30
2. [학술지(정기간행물)] - Levy ML / 1996 / Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer’s disease / Am J Psychiatry 153 : 1438 ~ 1443
4. [단행본] - World Health Organization / 1995 / World Health Organization Quality of Life-100 / World Health Organization, Division of Mental Health
5. [학술지(정기간행물)] - 홍석경 / 2002 / 파킨슨병 환자의 삶의 질 / 대한신경과학회지 20 (3) : 227 ~ 233
6. [단행본] - Logsdon RG / 2000 / Quality of life in Alzheimer’s disease: patient and caregiver reports, in Assessing Quality of Life in Alzheimer’s Disease / Spring Publishing Company : 17 ~ 30
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UCI(KEPA) : I410-ECN-0101-2014-513-000468534