지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.84 No.1
- 발행연도
- 2013.1
- 수록면
- 9 - 17 (9page)
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초록· 키워드
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Purpose: We evaluated the relationship between the degree of osteopontin (OPN) expression in papillary thyroid carcinoma (PTC) specimens and the presence of the BRAF mutation and clinicopathologic variables. Methods: Fifty-six snap-frozen thyroid tumor samples, including those of 49 PTCs, four follicular adenomas, two follicular carcinomas, and one Hurthle cell adenoma, were studied. We performed reverse transcription-polymerase chain reaction (RT-PCR) to assess the OPN expression levels. We also tested the BRAF codon 599 mutations using RT-PCR with the direct sequencing method. All of the tumors were microscopically reexamined by a pathologist with a special interest in thyroid neoplasia. Results: OPN mRNA was significantly overexpressed in the PTC samples compared with other thyroid tumors (P = 0.011). In PTCs, the OPN expression level was higher in the BRAF mutation group than in the wild-type group (P = 0.041). Among the clinicopathologic variables, nonfollicular variant histologic subtypes (P = 0.002) and the presence of lymph node metastases (P = 0.042) were correlated with elevated level of OPN expression. Conclusion: OPN might play a crucial role in tumorigenesis and the progression of PTC.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
REFERENCES
참고문헌 (29)
참고문헌 신청
1. [단행본] - DeLellis RA / 2004 / Thyroid and parathyroid tumors, In Pathology and genetics of tumours of endocrine organs / IARC Press : 51 ~ 56
2. [학술지(정기간행물)] - Pelizzo MR / 2004 / Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience / Nucl Med Commun 25 : 547 ~ 552
3. [학술지(정기간행물)] - Takahashi M / 1985 / Activation of a novel human transforming gene, ret, by DNA rearrangement / Cell 42 : 581 ~ 588
4. [학술지(정기간행물)] - Airaksinen MS / 2002 / The GDNF family: signalling, biological functions and therapeutic value / Nat Rev Neurosci 3 : 383 ~ 394
5. [학술지(정기간행물)] - Grieco M / 1990 / PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas / Cell 60 : 557 ~ 563
2. [학술지(정기간행물)] - Pelizzo MR / 2004 / Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience / Nucl Med Commun 25 : 547 ~ 552
3. [학술지(정기간행물)] - Takahashi M / 1985 / Activation of a novel human transforming gene, ret, by DNA rearrangement / Cell 42 : 581 ~ 588
4. [학술지(정기간행물)] - Airaksinen MS / 2002 / The GDNF family: signalling, biological functions and therapeutic value / Nat Rev Neurosci 3 : 383 ~ 394
5. [학술지(정기간행물)] - Grieco M / 1990 / PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas / Cell 60 : 557 ~ 563
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UCI(KEPA) : I410-ECN-0101-2014-514-000359640