Protective effects of Korean red ginseng extract on cadmium-induced hepatic toxicity in rats

Sook Jahr Park; Jong Rok Lee; Mi Jeong Jo; Sang Mi Park; Sae Kwang Ku; Sang Chan Kim

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자료유형: 학술저널

저자정보: Sook Jahr Park (Daegu Haany University) Jong Rok Lee (Daegu Haany University) Mi Jeong Jo (Daegu Haany University) Sang Mi Park (Daegu Haany University) Sae Kwang Ku (Daegu Haany University) Sang Chan Kim (Daegu Haany University)

저널정보: 고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.37 No.1

발행연도: 2013.1

수록면: 37 - 44 (8page)

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Korean red ginseng is known to regulate the immune system and help the body struggle infection and disease. Cadmium is widely distributed in the environment due to its use in industry. Exposure to cadmium is problematic causing organ dysfunction. This study was conducted to evaluate the protective effect of Korean red ginseng extract (RGE) against cadmium-induced hepatotoxicity in rats. In experiments, animals were orally administrated with RGE (25, 50 mg/kg) for 7 d and then intravenously injected with cadmium (CdCl2, 4 mg/kg) to induce acute hepatotoxicity. Cadmium caused the elevated levels of alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase in serum. In contrast, pretreatment with RGE significantly reduced those serum indexes related with liver damage. In histopathological analysis, RGE decreased the centrilobular necrosis around central veins and the peripheral hemorrhage around portal triads. Moreover, RGE restored the deficit in hepatic glutathione level resulting from cadmium treatment. RGE also inhibited the increase in the expression of Bad, a representative apoptosis marker protein, induced by cadmium treatment. Collectively, these results demonstrate that RGE can reduce the cadmium-induced hepatic toxicity, partly via anti-oxidative and anti-apoptotic process.

#Panax ginseng #Korean red ginseng #Cadmium #Hepatic toxicity #Hepatoprotection

참고문헌 (35)

참고문헌 신청

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