지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: The present study investigated the effects of acupuncture treatment and their mechanism by using the kainic acid (KA)-induced epilepsy mouse model.
Materials and Methods: The seizure was induced by an intraperitoneal (i.p.) injection of 30 mg/kg KA, and the acupuncture treatment was subsequently administered to acupoint Shaofu(HT8) bilaterally with two pretreatment sessions before injection (total 3 times over 3 days). Twenty four hours after injection, we observed thesurvival of neuronal cells in the CA3 region of the hippocampus. In addition, the activation of microglia and astrocytes was observed by using CD11b and GFAP immunohistochemistry in the same region.
Results: The results indicate that acupuncture treatment reduced the rate of neural cell death in the CA3 region of the hippocampus and decreased the activations of microglia and astrocytes in this region.
Conclusion: These results demonstrate that acupuncture treatment protects hippocampal neuronal cell death from KA-induced epileptic seizure by inhibiting the activations of microglia and astrocytes.
Materials and Methods: The seizure was induced by an intraperitoneal (i.p.) injection of 30 mg/kg KA, and the acupuncture treatment was subsequently administered to acupoint Shaofu(HT8) bilaterally with two pretreatment sessions before injection (total 3 times over 3 days). Twenty four hours after injection, we observed thesurvival of neuronal cells in the CA3 region of the hippocampus. In addition, the activation of microglia and astrocytes was observed by using CD11b and GFAP immunohistochemistry in the same region.
Results: The results indicate that acupuncture treatment reduced the rate of neural cell death in the CA3 region of the hippocampus and decreased the activations of microglia and astrocytes in this region.
Conclusion: These results demonstrate that acupuncture treatment protects hippocampal neuronal cell death from KA-induced epileptic seizure by inhibiting the activations of microglia and astrocytes.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (49)
참고문헌 신청
1. [단행본] - 김덕곤 / 1998 / 동의간질학 / 서원당 : 23 ~ 309
2. [단행본] - 안효섭 / 2005 / 소아과학 제8판 / 대한교과서 : 1060 ~ 1075
3. [학술지(정기간행물)] - Na WK / 2004 / A case report of epileptic children / The journal of Korean Oriental Pediatrics 18 (1) : 131 ~ 138
4. [단행본] - 임종국 / 2001 / 침구치료학 / 집문당 : 333 ~
5. [학술지(정기간행물)] - 신동훈 / 2004 / 대돈,소부 사법자침이 뇌혈류력학 변동 개선에 미치는 영향 / 대한침구학회지 21 (1) : 33 ~ 50
2. [단행본] - 안효섭 / 2005 / 소아과학 제8판 / 대한교과서 : 1060 ~ 1075
3. [학술지(정기간행물)] - Na WK / 2004 / A case report of epileptic children / The journal of Korean Oriental Pediatrics 18 (1) : 131 ~ 138
4. [단행본] - 임종국 / 2001 / 침구치료학 / 집문당 : 333 ~
5. [학술지(정기간행물)] - 신동훈 / 2004 / 대돈,소부 사법자침이 뇌혈류력학 변동 개선에 미치는 영향 / 대한침구학회지 21 (1) : 33 ~ 50
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UCI(KEPA) : I410-ECN-0101-2014-519-000284690