지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective: The antiplatelet agent aspirin has been widely used for treating atherosclerosis in western medicine, and its efficacy has been proven in cardiac and extracardiac vascular diseases. On the other hand, Hyeolbuchukeo-tang has been widely used for treating blood stasis syndrome in traditional medicine. Therefore we investigated whether Hyeolbuchukeo-tang could have a synergic effect along with aspirin.
Methods & Materials: Male ApoE<SUP>(-/-)</SUP> mice were randomly divided into three different experimental groups: a non-treated group(Control group), an aspirin-treated group(AP group), and an aspirin with Hyeolbuchukeo-tang-treated group(APH group). The control group was fed only an atherogenic diet, the AP group an atherogenic diet plus Aspirin 5 ㎎/㎏, and the APH group an atherogenic diet plus Aspirin 5 ㎎/㎏ with Hyeolbuchukeo-tang 100 ㎎/㎏. We investigated plasma lipid with liver function test, and performed the histological investigation of liver and abdominal aorta.
Results:
1. We investigated photomicrographic changes of liver and abdominal aorta tissue. They showed that histological injury of aorta and lipid accumulations of the liver were lower in the AP and APH groups than in the control group.
2. In the APH group, plasma triglyceride levels were significantly lower than those in the control and AP groups.
3. There were no differences in aspartate aminotransferase and alanine aminotransferase levels among the control, AP and APH groups.
Conclusion: The above results show that a combined treatment of Hyeolbuchukeo-tang and aspirin has a somewhat synergic effect in terms of inhibiting vessel injury and decreasing lipid deposits on liver cells without liver toxicity.
Methods & Materials: Male ApoE<SUP>(-/-)</SUP> mice were randomly divided into three different experimental groups: a non-treated group(Control group), an aspirin-treated group(AP group), and an aspirin with Hyeolbuchukeo-tang-treated group(APH group). The control group was fed only an atherogenic diet, the AP group an atherogenic diet plus Aspirin 5 ㎎/㎏, and the APH group an atherogenic diet plus Aspirin 5 ㎎/㎏ with Hyeolbuchukeo-tang 100 ㎎/㎏. We investigated plasma lipid with liver function test, and performed the histological investigation of liver and abdominal aorta.
Results:
1. We investigated photomicrographic changes of liver and abdominal aorta tissue. They showed that histological injury of aorta and lipid accumulations of the liver were lower in the AP and APH groups than in the control group.
2. In the APH group, plasma triglyceride levels were significantly lower than those in the control and AP groups.
3. There were no differences in aspartate aminotransferase and alanine aminotransferase levels among the control, AP and APH groups.
Conclusion: The above results show that a combined treatment of Hyeolbuchukeo-tang and aspirin has a somewhat synergic effect in terms of inhibiting vessel injury and decreasing lipid deposits on liver cells without liver toxicity.
목차
서론
실험재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (0)
참고문헌 신청이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-519-000285122