지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.84 No.4
- 발행연도
- 2013.4
- 수록면
- 231 - 237 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) are the most frequently used tumor markers in the clinical setting of colorectal cancer (CRC). This study was designed to investigate the correlation between preoperative serum levels of CA 19-9 (pre-CA 19-9) and the clinicopathologic factors of patients with CRC. Methods: A study was performed on 333 patients with histologically diagnosed colorectal adenocarcinoma between December 2008 and November 2011, based on prospective collected data. The clinical data such as age, sex, location of tumor, size of tumor, differentiation, depth of tumor (T), lymph node metastasis (N), distant metastasis (M), lymphatic invasion, venous invasion, perineural invasion, stage, and preoperative serum levels of CEA (pre-CEA) and pre-CA 19-9 were obtained. These patients were classified into two groups according to pre-CA 19-9 (CA 19-9 high: ＞39 U/mL, n = 61 [18.3%]; CA 19-9 normal: ＜39 U/mL, n = 272 [81.7%]). Results: Sixty-one patients among 333 patients (18.3%) with CRC showed a high pre-CA 19-9. The elevation of pre-CA 19-9 was significantly associated with size of tumor (4.8 ± 0.1 cm vs. 6.1 ± 0.3 cm, P ＜ 0.001), right colon cancer (P ＜ 0.001), depth of tumor (P ＜ 0.001), lymph node metastasis (P ＜ 0.001), distant metastasis (P ＜ 0.001), perineural invasion (P = 0.008), peritoneal seeding (P ＜ 0.001), and stage (P ＜ 0.001). On multivariate analysis, high pre-CA 19-9 was shown to be independently associated with high pre-CEA, lymph node metastasis, right colon cancer, large tumor size, and peritoneal
seeding. There were twelve patients confirmed for peritoneal seeding among 333 patients (3.6%). Conclusion: High pre-CA 19-9 in advanced colorectal cancer might provide important information to predict the possibility of peritoneal seeding.
seeding. There were twelve patients confirmed for peritoneal seeding among 333 patients (3.6%). Conclusion: High pre-CA 19-9 in advanced colorectal cancer might provide important information to predict the possibility of peritoneal seeding.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Yamashita K / 2009 / Clinical significance of tumor markers and an emerging perspective on colorectal cancer / Cancer Sci 100 : 195 ~ 199
2. [학술지(정기간행물)] - Bast RC Jr / 2001 / 2000 update of recommendations for the use of tumor markers in breast and colorectal cancer: clinical practice guidelines of the American Society of Clinical Oncology / J Clin Oncol 19 : 1865 ~ 1878
3. [학술지(정기간행물)] - Goonetilleke KS / 2007 / Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer / Eur J Surg Oncol 33 : 266 ~ 270
4. [학술지(정기간행물)] - Zheng CX / 2001 / The prognostic value of preoperative serum levels of CEA, CA19-9 and CA72-4 in patients with colorectal cancer / World J Gastroenterol 7 : 431 ~ 434
5. [단행본] - Tan MC / 2007 / Disorders of the anal canal, In Sabiston textbook of surgery: the biological basis of modern surgical practice. 18th ed / WB Saunders : 761 ~
2. [학술지(정기간행물)] - Bast RC Jr / 2001 / 2000 update of recommendations for the use of tumor markers in breast and colorectal cancer: clinical practice guidelines of the American Society of Clinical Oncology / J Clin Oncol 19 : 1865 ~ 1878
3. [학술지(정기간행물)] - Goonetilleke KS / 2007 / Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer / Eur J Surg Oncol 33 : 266 ~ 270
4. [학술지(정기간행물)] - Zheng CX / 2001 / The prognostic value of preoperative serum levels of CEA, CA19-9 and CA72-4 in patients with colorectal cancer / World J Gastroenterol 7 : 431 ~ 434
5. [단행본] - Tan MC / 2007 / Disorders of the anal canal, In Sabiston textbook of surgery: the biological basis of modern surgical practice. 18th ed / WB Saunders : 761 ~
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-510-003019574