지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.84 No.6
- 발행연도
- 2013.6
- 수록면
- 313 - 320 (8page)
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초록· 키워드
오류제보하기
Purpose: The empirical use of a chemotherapy regimen shows different results in individual breast cancer patient treatment. Recent studies showed the effectiveness of the adenosine triphosphate-based chemotherapy response assay (ATP-CRA). However, little is known about the correlation between chemosensitivity and breast cancer molecular subtypes. Therefore, we investigated whether the result of ATP-CRA is associated with a molecular subtype of breast cancer. Methods: Two hundred eighty-seven patients diagnosed with breast cancer and receiving ATP-CRA at Mokdong Hospital, Ewha Womans University between September 2007 and December 2010 were enrolled in this study. Hormone receptor status, HER2/neu expression, and results of chemosensitivity tests of the patients was analyzed. Results: In all of four subtypes, the combination of two agents showed significant higher mean cell death rate than a single agent. Within the breast cancer cell lines in this study, the range of chemosensitivity response was very wide and varied for each patient. For this reason, the molecular subtype of breast cancer is inconclusive in choosing an effective chemotherapeutic agent and in vitro chemosensitivity test, prior to therapy, could be a useful method for planning chemotherapy for each patient. Conclusion: Chemosensitivity response to anticancer agents was found to vary depending on the individual breast cancer patients. The molecular subtype of breast cancer is inconclusive to choose the effective chemotherapeutic agent and the in vitro chemosensitivity test, prior to therapy, could be more useful for planning chemotherapy for each patient.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
1. [학술지(정기간행물)] - Parkin DM / 2005 / Global cancer statistics, 2002 / CA Cancer J Clin 55 : 74 ~ 108
2. [보고서] - Ministry of Health and Welfare, Korea Central Cancer Registry, National Cancer Center / 2010 / Annual report of cancer statistics in Korea in 2008
3. [학술지(정기간행물)] - Takamura Y / 2002 / Prediction of chemotherapeutic response by collagen gel droplet embedded culture-drug sensitivity test in human breast cancers / Int J Cancer 98 : 450 ~ 455
4. [학술지(정기간행물)] - Kern DH / 1985 / Development of a miniaturized, improved nucleic acid precursor incorporation assay for chemosensitivity testing of human solid tumors / Cancer Res 45 (11 Pt 1) : 5436 ~ 5441
5. [학술지(정기간행물)] - Tanigawa N / 1992 / In vitro growth ability and chemosensitivity of gastric and colorectal cancer cells assessed with the human tumour clonogenic assay and the thymidine incorporation assay / Eur J Cancer 28 : 31 ~ 34
2. [보고서] - Ministry of Health and Welfare, Korea Central Cancer Registry, National Cancer Center / 2010 / Annual report of cancer statistics in Korea in 2008
3. [학술지(정기간행물)] - Takamura Y / 2002 / Prediction of chemotherapeutic response by collagen gel droplet embedded culture-drug sensitivity test in human breast cancers / Int J Cancer 98 : 450 ~ 455
4. [학술지(정기간행물)] - Kern DH / 1985 / Development of a miniaturized, improved nucleic acid precursor incorporation assay for chemosensitivity testing of human solid tumors / Cancer Res 45 (11 Pt 1) : 5436 ~ 5441
5. [학술지(정기간행물)] - Tanigawa N / 1992 / In vitro growth ability and chemosensitivity of gastric and colorectal cancer cells assessed with the human tumour clonogenic assay and the thymidine incorporation assay / Eur J Cancer 28 : 31 ~ 34
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UCI(KEPA) : I410-ECN-0101-2014-510-002571331