지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 221 - 228 (8page)
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초록· 키워드
오류제보하기
Rodent malaria parasites, such as Plasmodium berghei, are practical and useful model organisms for human malaria research because of their analogies to the human malaria in terms of structure, physiology, and life cycle. Exploiting the available genetic sequence information, we constructed a cDNA library from the erythrocytic stages of P. berghei and analyzed the expressed sequence tag (EST). A total of 10,040 ESTs were generated and assembled into 2,462 clusters. These EST clusters were compared against public protein databases and 48 putative new transcripts, most of which were hypothetical proteins with unknown function, were identified. Genes encoding ribosomal or membrane proteins and purine nucleotide phosphorylases were highly abundant clusters in P. berghei. Protein domain analyses and the Gene Ontology functional categorization revealed translation/protein folding, metabolism, protein degradation, and multiple family of variant antigens to be mainly prevalent. The presently-collected ESTs and its bioinformatic analysis will be useful resources to identify for drug target and vaccine candidates and validate gene predictions of P. berghei.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Janse CJ / 1994 / Conserved location of genes on polymorphic chromosomes of four species of malaria parasites / Mol Biochem Parasitol 68 : 285 ~ 296
2. [학술지(정기간행물)] - Rich SM / 2003 / Progress in malaria research: The case for phylogenetics / Adv Parasitol 54 : 255 ~ 280
3. [학술지(정기간행물)] - Booker ML / / Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model / J Biol Chem 285 : 33054 ~ 33064
4. [학술지(정기간행물)] - Hall N / 2005 / A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses / Science 307 : 82 ~ 86
5. [학술지(정기간행물)] - Gardner MJ / 2002 / Genome sequence of the human malaria parasite Plasmodium falciparum / Nature 419 : 498 ~ 511
2. [학술지(정기간행물)] - Rich SM / 2003 / Progress in malaria research: The case for phylogenetics / Adv Parasitol 54 : 255 ~ 280
3. [학술지(정기간행물)] - Booker ML / / Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model / J Biol Chem 285 : 33054 ~ 33064
4. [학술지(정기간행물)] - Hall N / 2005 / A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses / Science 307 : 82 ~ 86
5. [학술지(정기간행물)] - Gardner MJ / 2002 / Genome sequence of the human malaria parasite Plasmodium falciparum / Nature 419 : 498 ~ 511
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UCI(KEPA) : I410-ECN-0101-2014-510-002511333