지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 109 - 114 (6page)
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초록· 키워드
오류제보하기
Dendritic cells have been known as a member of strong innate immune cells against infectious organelles. In this study, we evaluated the cytokine expression of splenic dendritic cells in chronic mouse toxoplasmosis by tissue cyst-forming Me49 strain and demonstrated the distribution of lymphoid dendritic cells by fluorescence-activated cell sorter (FACS). Pro-inflammatory cytokines, such as IL-1α, IL-1β, IL-6, and IL-10 increased rapidly at week 1 post-infection (PI) and peaked at week 3 PI. Serum IL-10 level followed the similar patterns. FACS analysis showed that the number of CD8α+/ CD11c+ splenic dendritic cells increased at week 1 and peaked at week 3 PI. In conclusion, mouse splenic dendritic cells showed early and rapid cytokine changes and may have important protective roles in early phases of murine toxoplasmosis.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Choi WY / 1997 / Foodborne outbreaks of human toxoplasmosis / J Infect Dis 175 : 1280 ~ 1282
2. [학술지(정기간행물)] - Dubey JP / 1998 / Advances in the life cycle of Toxoplasma gondii / Int J Parasitol 28 : 1019 ~ 1024
3. [학술지(정기간행물)] - Banchereau J / 2000 / Immunobiology of dendritic cells / Annu Rev Immunol 18 : 767 ~ 811
4. [학술지(정기간행물)] - Liu CH / 2006 / Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice / J Immunol 177 : 31 ~ 35
5. [학술지(정기간행물)] - Suzuki Y / 1988 / Interferon-gamma: the major mediator of resistance against Toxoplasma gondii / Science 240 : 516 ~ 518
2. [학술지(정기간행물)] - Dubey JP / 1998 / Advances in the life cycle of Toxoplasma gondii / Int J Parasitol 28 : 1019 ~ 1024
3. [학술지(정기간행물)] - Banchereau J / 2000 / Immunobiology of dendritic cells / Annu Rev Immunol 18 : 767 ~ 811
4. [학술지(정기간행물)] - Liu CH / 2006 / Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice / J Immunol 177 : 31 ~ 35
5. [학술지(정기간행물)] - Suzuki Y / 1988 / Interferon-gamma: the major mediator of resistance against Toxoplasma gondii / Science 240 : 516 ~ 518
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UCI(KEPA) : I410-ECN-0101-2014-510-002511540