지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 79 - 83 (5page)
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초록· 키워드
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Trichomoniasis is a sexually transmitted disease due to infection with Trichomonas vaginalis, and it can cause serious consequences for women’s health. To study the virulence factors of this pathogen, T. vaginalis surface proteins were investigated using polyclonal antibodies specific to the membrane fractions of T. vaginalis. The T. vaginalis expression library was constructed by cloning the cDNA derived from mRNA of T. vaginalis into a phage λ Uni-ZAP XR vector, and then used for immunoscreening with the anti-membrane proteins of T. vaginalis antibodies. The immunoreactive proteins identified included adhesion protein AP65-1, α-actinin, kinesin-associated protein, teneurin, and 2 independent hypothetical proteins. Immunofluorescence assays showed that AP65-1, one of the identified immunogenic clones, is prevalent in the whole body of T. vaginalis. This study led us to identify T. vaginalis proteins which may stimulate immune responses by human cells.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Van der Pol B / 2007 / Trichomonas vaginalis infection: the most prevalent nonviral sexually transmitted infection receives the least public health attention / Clin Infect Dis 44 : 23 ~ 25
2. [학술지(정기간행물)] - Lehker MW / 1999 / Trichomonad invasion of the mucous layer requires adhesins, mucinases, and motility / Sex Transm Infect 75 : 231 ~ 238
3. [학술지(정기간행물)] - Lehker MW / 1992 / Iron regulates growth of Trichomonas vaginalis and the expression of immunogenic trichomonad proteins / Mol Microbiol 6 : 123 ~ 132
4. [학술지(정기간행물)] - Crouch ML / 1999 / Trichomonas vaginalis interactions with fibronectin and laminin / Microbiology 145 : 2835 ~ 2843
5. [학술지(정기간행물)] - Tsai CD / 2002 / Characterization of an iron-responsive promoter in the protozoan pathogen Trichomonas vaginalis / J Biol Chem 277 : 5153 ~ 5162
2. [학술지(정기간행물)] - Lehker MW / 1999 / Trichomonad invasion of the mucous layer requires adhesins, mucinases, and motility / Sex Transm Infect 75 : 231 ~ 238
3. [학술지(정기간행물)] - Lehker MW / 1992 / Iron regulates growth of Trichomonas vaginalis and the expression of immunogenic trichomonad proteins / Mol Microbiol 6 : 123 ~ 132
4. [학술지(정기간행물)] - Crouch ML / 1999 / Trichomonas vaginalis interactions with fibronectin and laminin / Microbiology 145 : 2835 ~ 2843
5. [학술지(정기간행물)] - Tsai CD / 2002 / Characterization of an iron-responsive promoter in the protozoan pathogen Trichomonas vaginalis / J Biol Chem 277 : 5153 ~ 5162
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UCI(KEPA) : I410-ECN-0101-2014-510-002511833