지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 285 - 290 (6page)
이용수
초록· 키워드
오류제보하기
Tyrosine kinases are one of the most important regulators for intracellular signal transduction related to inflammatory responses. However, there are no reports describing the effects of tyrosine kinases on neutrophil apoptosis induced by Entamoeba histolytica. In this study, isolated human neutrophils from peripheral blood were incubated with live trophozoites in the presence or absence of tyrosine kinase inhibitors. Entamoeba-induced receptor shedding of CD16 and PS externalization in neutrophils were inhibited by pre-incubation of neutrophils with the broad-spectrum tyrosine kinase inhibitor genistein or the Src family kinase inhibitor PP2. Entamoeba-induced ROS production was also inhibited by genistein or PP2. Moreover, genistein and PP2 blocked the phosphorylation of ERK and p38 MAPK in neutrophils induced by E. histolytica. These results suggest that Src tyrosine kinases may participate in the signaling event for ROS-dependent activation of MAPKs during neutrophil apoptosis induced by E. histolytica.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
Guo X / 2007 / Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies / Curr Opin Immunol 19:376~384
Dey I / 2008 / Prostaglandin E2 produced by Entamoeba histolytica binds to EP4 receptors and stimulates interleukin-8 production in human colonic cells / Infect Immun 76:5158~5163
Zhelev DV / 2002 / Signaling in the motility responses of the human neutrophil / Ann Biomed Eng 30:356~370
Jarillo-Luna RA / 2002 / Entamoeba histolytica: immunohistochemical study of hepatic amoebiasis in mouse. Neutrophils and nitric oxide as possible factors of resistance / Exp Parasitol 101:40~56
Rivero-Nava L / 2002 / Entamoeba histolytica: acute granulomatous intestinal lesions in normal and neutrophil-depleted mice / Exp Parasitol 101:183~192
Dey I / 2008 / Prostaglandin E2 produced by Entamoeba histolytica binds to EP4 receptors and stimulates interleukin-8 production in human colonic cells / Infect Immun 76:5158~5163
Zhelev DV / 2002 / Signaling in the motility responses of the human neutrophil / Ann Biomed Eng 30:356~370
Jarillo-Luna RA / 2002 / Entamoeba histolytica: immunohistochemical study of hepatic amoebiasis in mouse. Neutrophils and nitric oxide as possible factors of resistance / Exp Parasitol 101:40~56
Rivero-Nava L / 2002 / Entamoeba histolytica: acute granulomatous intestinal lesions in normal and neutrophil-depleted mice / Exp Parasitol 101:183~192
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
암치료의 새로운 target
KSCO News&Education
2008 .12
-
Stimulatory Effect of Ginsenosides on $pp60^{c-src}$ Protein Tyrosine Kinase
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1993 .01
-
Differentiation of Korean isolates of Entamoeba histolytica from Entamoeba dispar
Parasites, Hosts and Diseases
1996 .03
-
Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin-induced β‐cell apoptosis
한국실험동물학회 학술발표대회 논문집
2015 .08
-
이질아메바(Entamoeba histolytica)의 미세구조 및 효소활성에 관한 전자현미경적 연구
Parasites, Hosts and Diseases
1985 .12
-
Characterization of YS-27, an axenic Korean strain of Entamoeba histolytica
Parasites, Hosts and Diseases
1999 .03
-
Studies on the Activation Mechanism of c-src Protein Tyrosine Kinase by Ginsenoside-Rg_1_
Journal of Ginseng Research
1998 .06
-
Amoebic PI3K and PKC Is Required for Jurkat T Cell Death Induced by Entamoeba histolytica
Parasites, Hosts and Diseases
2014 .08
-
Current Understanding in Neutrophil Differentiation and Heterogeneity
Immune Network
2017 .10
-
Different Clinical Outcomes of Entamoeba histolytica in Malaysia: Does Genetic Diversity Exist?
Parasites, Hosts and Diseases
2013 .04
-
Entamoeba histolytica Induces Cell Death of HT29 Colonic Epithelial Cells via NOX1-Derived ROS
Parasites, Hosts and Diseases
2013 .02
-
[지상 34] Protective effect of activated ERK1/2 in TRAIL-induced apoptosis via tyrosine kinase pathway
대한체질인류학회 학술대회 연제 초록
2005 .05
-
Effect of Iron on Adherence and Cytotoxicity of Entamoeba histolytica to CHO Cell Monolayers
Parasites, Hosts and Diseases
2008 .03
-
Tyrosine Kinase is Involved in Hemin-Induced Pyresis
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
Overview of Entamoeba histolytica and Amebiasis in Korea with Special Reference to Research Notes
Parasites, Hosts and Diseases
1990 .10
-
Degradation of the Transcription Factors NF-κB, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells
Parasites, Hosts and Diseases
2014 .10
-
Inhibitory Effects of Iranian Thymus vulgaris Extracts on in Vitro Growth of Entamoeba histolytica
Parasites, Hosts and Diseases
2008 .09
-
말초혈액 단핵구에 대한 내독소 자극의 신호 전달에서 Protein Kinase C와 Protein Tyrosine Kinase의 역할
Tuberculosis and Respiratory Diseases
1997 .01
-
Role of Retinoic Acid in Spontaneous Apoptosis of Human Neutrophils
대한의생명과학회지
2007 .12
-
급성 폐손상에서 호중구 활성화의 분자학적 기전
Tuberculosis and Respiratory Diseases
2002 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-510-002511888