지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 87 - 90 (4page)
이용수
초록· 키워드
오류제보하기
The potential role of topical valproate (VPA) in hair regrowth has been recently suggested. However, safety reports of VPA as a topical formulation are lacking. Therefore, in the present study, we investigated whether VPA causes skin irritation in humans. We first performed a cell viability test and showed that VPA did not exhibit toxicity toward HaCaT keratinocytes, fibroblasts, and RBL-3H mast cells. We then performed clinical patch test and skin irritation test through transdermal drug delivery with the help of microneedle rollers. No significant findings were obtained in the clinical patch test. In the skin irritation test, only 1 patient showed erythema at 1 hr, but the irritation reaction faded away within a few hours. Erythema and edema were not observed at 24 hr. We concluded that VPA has minimal potential to elicit skin irritation. Therefore, we consider that VPA can safely be applied to human skin.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (10)
참고문헌 신청
Reynolds, M. F. / 2007 / Valproate and neuroendocrine changes in relation to women treated for epilepsy and bipolar disorder: a review / Curr. Med. Chem. 14:2799~2812
Tennis, P. / 1997 / Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: a record linkage study / Neurol. 49:542~546
Roujeau, J. C. / 1995 / Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis / N. Engl. J. Med. 333:1600~1607
Lee, S. H. / 2012 / Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells / PLoS One 7:e34152
Andl, T. / 2002 / WNT signals are required for the initiation of hair follicle development / Dev. Cell 2:643~653
Tennis, P. / 1997 / Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: a record linkage study / Neurol. 49:542~546
Roujeau, J. C. / 1995 / Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis / N. Engl. J. Med. 333:1600~1607
Lee, S. H. / 2012 / Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells / PLoS One 7:e34152
Andl, T. / 2002 / WNT signals are required for the initiation of hair follicle development / Dev. Cell 2:643~653
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-510-003293190