지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.85 No.1
- 발행연도
- 2013.7
- 수록면
- 15 - 19 (5page)
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초록· 키워드
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Purpose: Thyroid stimulating hormone (TSH) measurement is the most sensitive screening test for thyroid dysfunction. TSH is a well-known thyroid growth factor but its pathogenic role in thyroid oncogenesis remains to be clarified. The purpose of the present study was to evaluate the relationship between clinicopathologic characteristics of nonfunctioning thyroid nodules and preoperative TSH serum concentrations.
Methods: Serum TSH concentrations can be affected by many factors. After exclusion of these confounding factors, a total of 126 patients who underwent thyroidectomy from Januray 2009 to December 2010 were included in this study. Average age was 45.4 ± 10.6 years and male:female ratio was 1:2.9. There were 11 patients with benign nodules, 34 patients with papillary thyroid microcarcinoma (PTMC) of less than 5 mm in maximal diameter, 66 patients with PTMCs of more than 5 mm but not more than 10 mm in maximal diameter, and 15 patients with papillary thyroid carcinoma (PTC) of more than 10 mm in maximal diameter.
Results: TNM stages of PTCs correlated with higher preoperative TSH serum concentrations. There were trends of higher preoperative TSH serum concentrations in patients who had extrathyroidal extension (P = 0.059) and advanced N stages (P = 0.120) but did not reach statistical significance. Patients’ age, sex, and tumor volume did not seem to affect preoperative TSH serum concentrations significantly.
Conclusion: In patients who have PTCs without clinical, immunological, or ultrasonographic evidence of thyroiditis, higher preoperative TSH serum concentrations within the normal range might suggest advanced TNM stages.
Methods: Serum TSH concentrations can be affected by many factors. After exclusion of these confounding factors, a total of 126 patients who underwent thyroidectomy from Januray 2009 to December 2010 were included in this study. Average age was 45.4 ± 10.6 years and male:female ratio was 1:2.9. There were 11 patients with benign nodules, 34 patients with papillary thyroid microcarcinoma (PTMC) of less than 5 mm in maximal diameter, 66 patients with PTMCs of more than 5 mm but not more than 10 mm in maximal diameter, and 15 patients with papillary thyroid carcinoma (PTC) of more than 10 mm in maximal diameter.
Results: TNM stages of PTCs correlated with higher preoperative TSH serum concentrations. There were trends of higher preoperative TSH serum concentrations in patients who had extrathyroidal extension (P = 0.059) and advanced N stages (P = 0.120) but did not reach statistical significance. Patients’ age, sex, and tumor volume did not seem to affect preoperative TSH serum concentrations significantly.
Conclusion: In patients who have PTCs without clinical, immunological, or ultrasonographic evidence of thyroiditis, higher preoperative TSH serum concentrations within the normal range might suggest advanced TNM stages.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (15)
참고문헌 신청
Matsuo K / 1993 / The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms / J Clin Endocrinol Metab 76:1446~1451
Derwahl M / 1999 / Clinical review 101: thyrotropin may not be the dominant growth factor in benign and malignant thyroid tumors / J Clin Endocrinol Metab 84:829~834
Mazzaferri EL. / 2000 / Thyroid cancer and Graves' disease: the controversy ten years later / Endocr Pract 6:221~225
Shi Y / 1993 / Expression of thyrotrophin receptor gene in thyroid carcinoma is associated with a good prognosis / Clin Endocrinol (Oxf) 39:269~274
Papini E / 1998 / Long-term changes in nodular goiter: a 5-year prospective randomized trial of levothyroxine suppressive therapy for benign cold thyroid nodules / J Clin Endocrinol Metab 83:780~783
Derwahl M / 1999 / Clinical review 101: thyrotropin may not be the dominant growth factor in benign and malignant thyroid tumors / J Clin Endocrinol Metab 84:829~834
Mazzaferri EL. / 2000 / Thyroid cancer and Graves' disease: the controversy ten years later / Endocr Pract 6:221~225
Shi Y / 1993 / Expression of thyrotrophin receptor gene in thyroid carcinoma is associated with a good prognosis / Clin Endocrinol (Oxf) 39:269~274
Papini E / 1998 / Long-term changes in nodular goiter: a 5-year prospective randomized trial of levothyroxine suppressive therapy for benign cold thyroid nodules / J Clin Endocrinol Metab 83:780~783
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UCI(KEPA) : I410-ECN-0101-2014-510-002955162