지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2012.7
- 수록면
- 758 - 763 (6page)
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초록· 키워드
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The aim of this work is to develop a novel biocompatible drug delivery carrier and tissue engineering scaffold with ability of controlled drug release and also tissue regeneration. We have synthesized HPMADMAEM copolymer based hydrogels loaded with Doxorubicin (DOX) and tested in vitro. In-vitro drug release profile exhibited pH sensitive behavior of the hydrogel. The hydrolytic degradation of gel and in vitro studies of polymer-doxorubicin conjugate and doxorubicin release from hydrogel matrix indicated that hydrogels were stable under acidic conditions (in buffers at pH 4.6. In both drug forms, polymer-doxorubicin conjugate and free doxorubicin could be released from the hydrogel scaffold at a rate depending directly on either the rate of drug diffusion from the hydrogel, or rate of hydrogel degradation or at rate controlled by a combination of the both processes. In-vitro analysis showed homogenous cell attachment and proliferation on synthesized hydrogel matrix.
목차
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Conclusion
References
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UCI(KEPA) : I410-ECN-0101-2014-560-002891450