This paper describes a method for Development of the upper limbs exoskeleton robot. To measure the relative force between the human and robot, we produced 2-axis F/T sensor using strain gage. Using the data obtained by 2-axis F/T sensor, we can control the robot’s actuators. In order to estimate the disturbance, disturbance observer was designed and applied. The simulation of the disturbance observer was performed by Matlab. And with wear experiments, good capabilities of the upper limbs exoskeleton robot was verified.