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Curcumin has diverse anticancer activities that lead to tumor growth inhibition of cancer cells and induction of apoptosis. Curcumin is involved in the regulation of multiple genes via transcription factors including NF-kB, STATs, AP1, and SP. Notch signaling plays critical roles in maintaining the balance between cell proliferation, differentiation and apoptosis, and thereby may contribute to the development of various cancers involving breast cancer. This study was to investigate the effects of curcumin on Notch1 gene expression and to explore the underlying mechanism. Here, we found that curcumin decreased the levels of Notch1 mRNA and protein in MDA-MB-231 human breast cancer cells, along with the downregulation of Sp family genes (Sp1, Sp2, Sp3, and Sp4). The repressive effect of curcumin on Notch1 gene transcription was confirmed by performing Notch1 promoter- driven reporter assay and three Sp-binding sites were identified on Notch1 promoter that may act as curcumin-respose elements. Moreover, treatment with mitramycin A, a specific Sp inhibitor, decreased the levels of Notch1 mRNA and protein in human breast cancer cells. Taken together, our results indicate
that Notch1 gene expression is downregulated by curcumin, at least in part, through the suppression of Sp family, which may lead to apoptosis in human breast cancer cells.
that Notch1 gene expression is downregulated by curcumin, at least in part, through the suppression of Sp family, which may lead to apoptosis in human breast cancer cells.
목차
Abstract
1. 서론
2. 재료 및 방법
3. 결과 및 고찰
4. 결론
REFERENCES
참고문헌 (17)
참고문헌 신청
1. [학술지(정기간행물)] - McSherry, E. A. / 2007 / Molecular basis of invasion in breast cancer / Cell Mol. Life Sci 64 : 3201 ~ 3218
2. [학술지(정기간행물)] - Mego, M. / 2010 / Molecular mechanisms of metastasis in breast cancer-clinical applications / Nat. Rev. Clin. Oncol 7 : 693 ~ 701
3. [학술지(정기간행물)] - Moiseeva, E. P. / 2009 / Dietary chemopreventive phytochemicals: too little or too much? / Cancer. Prev. Res 2 : 611 ~ 616
4. [학술지(정기간행물)] - Menon, V. P. / 2007 / Antioxidant and antiinflammatory properties of curcumin / Adv. Exp. Med. Biol 595 : 105 ~ 125
5. [학술지(정기간행물)] - Kunnumakkara, A. B. / 2008 / Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins / Cancer Lett 269 : 199 ~ 225
2. [학술지(정기간행물)] - Mego, M. / 2010 / Molecular mechanisms of metastasis in breast cancer-clinical applications / Nat. Rev. Clin. Oncol 7 : 693 ~ 701
3. [학술지(정기간행물)] - Moiseeva, E. P. / 2009 / Dietary chemopreventive phytochemicals: too little or too much? / Cancer. Prev. Res 2 : 611 ~ 616
4. [학술지(정기간행물)] - Menon, V. P. / 2007 / Antioxidant and antiinflammatory properties of curcumin / Adv. Exp. Med. Biol 595 : 105 ~ 125
5. [학술지(정기간행물)] - Kunnumakkara, A. B. / 2008 / Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins / Cancer Lett 269 : 199 ~ 225
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UCI(KEPA) : I410-ECN-0101-2014-400-002408712