지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.8
- 수록면
- 333 - 340 (8page)
이용수
초록· 키워드
오류제보하기
In this study, gemcitabine-loaded methoxy poly(ethylene glycol)-b-poly(L-lactide) (MPEG-PLLA) microparticles with different PEG block lengths were prepared by a W/O/W double emulsion technique. The present study focuses on the investigation of the influence of various preparative parameters such as the ratio of internal water phase and oil phase, polymer concentration, solvent composition of organic phase and salt concentration of external water phase on the morphology and encapsulation efficiency of the microparticles. The microparticles fabricated at high volume ratios of internal water phase to oil phase and at high polymer concentrations showed a relatively high encapsulation efficiency and low porosity. When a dichloromethane/ethyl acetate mixture was used as solvent, both the encapsulation efficiency and drug loading of the microparticles decreased as the level of ethyl acetate increased. The addition of a salt (NaCl) to the external water phase significantly improved the encapsulation efficiency up to 40%, and the microparticles became more spherical with their size and porosity decreased.
목차
Abstract
1. 서론
2. 재료 및 방법
3. 결과 및 고찰
4. 결론
References
참고문헌 (35)
참고문헌 신청
Dutt, M / 2001 / Sustained release of isoniazid from a single injectable dose of poly (D,L-lactide-co-glycolide) microparticles as a therapeutic approach towards tuberculosis / Int. J. Antimicrob. Agents 17:115~122
Amperiadou, A / 1995 / Controlled release salbutamol sulphate microcapsules prepared by emulsion solvent-evaporation technique and study on the release affected parameters / Int. J. Pharm 115:1~8
Zhang, P / 2007 / In vitro and in vivo evaluation of donepezil-sustained release microparticles for the treatment of Alzheimer’s disease / Biomater 28:1882~1888
Abdel-Rahman, S. I / 2009 / Preparation and comparative evaluation of sustained release metoclopramide hydrochloride matrix tablets / Saudi Pharm. J 17:283~288
Feng, S. S / 2003 / Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases / Chem. Eng. Sci 58:4087~4114
Amperiadou, A / 1995 / Controlled release salbutamol sulphate microcapsules prepared by emulsion solvent-evaporation technique and study on the release affected parameters / Int. J. Pharm 115:1~8
Zhang, P / 2007 / In vitro and in vivo evaluation of donepezil-sustained release microparticles for the treatment of Alzheimer’s disease / Biomater 28:1882~1888
Abdel-Rahman, S. I / 2009 / Preparation and comparative evaluation of sustained release metoclopramide hydrochloride matrix tablets / Saudi Pharm. J 17:283~288
Feng, S. S / 2003 / Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases / Chem. Eng. Sci 58:4087~4114
이 논문의 저자 정보
이 논문과 함께 이용한 논문
제2형 당뇨병 치료제인 Pioglitazone을 봉입하기 위한 PLGA 나노입자 제조 및 분석
우현주
,
김진수
,
김준기
외 4명
폴리머
2010
.11
식품용 변성전분 신제품 및 개발방향
민병철
식품과학과 산업
2014
.09
Preparation of Poly(L-lactide) Nanopaticles for Drug Delivery Using Supercritical Fluid(SCF) and Hydrophilic Co-solvent Modified SCF
Yu-Sung
,
Oh
,
Gang-Hoi
외 5명
한국생물공학회 학술대회
2004
.04
Inhibitory Effects of Fisetin-loaded Poly(D,L-lactide-co-glycolide) Nanoparticles on the Proliferation of Lung Cancer Cells
Tae-Jin Shim
,
Bong-Su Pa
,
k
외 4명
한국실험동물학회 학술발표대회 논문집
2012
.02
스웨덴 복지모델 유지의 정치학, 그 한국적 전망
안상훈
황해문화
2004
.06
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-400-002406096