지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Among the 16 hemagglutinin (HA) subtypes of avian influenza virus (AIV), only the H5 and H7 subtypes have caused highly pathogenic avian influenza (HPAI) in poultry. However, most H5 or H7 subtype viruses are categorized as low pathogenic avian influenza (LPAI). Some AIVs, including the H5 and H7 HPAI viruses, have shown the ability to infect humans directly. In this study, we describe the biological and molecular characterization of an H5N3 AIV (SBD/KR/KNU SYG06/06) isolated from spot-billed duck (Anas poecilorhyncha) in Korea. A phylogenetic analysis of the eight viral genes showed that the SBD/KR/KNU SYG06/06 isolate belongs to the Eurasian lineage and that the SBD/KR/KNU SYG06/06 isolate was clearly different from HPAI H5N1 strains, including human isolates and the Italian HPAI H5N2 strains. Additionally, no relationship was found between SBD/KR/KNU SYG06/06 and the Korean HPAI H5N1 isolates. The SBD/KR/KNU SYG06/06 isolate had avian specific receptor binding site residues in the HA protein and the four C-terminal amino acids in the NS1 protein. The HA protein of the SBD/KR/KNU SYG06/06 isolate exhibited the typical LPAI motif at the cleavage site and this virus produced no cytopathic effects in MDCK cells without trypsin. Given these results, we suggest that the H5N3 AIV isolated from the spot-billed duck should be considered an LPAI virus and should have no pathogenic effect in humans.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (31)
참고문헌 신청
Banks J / 2001 / Changes in the haemagglutinin and the neuraminidase genes prior to the emergence of highly pathogenic H7N1 avian influenza viruses in Italy / Arch Virol 146:963~973
Campitelli L / 2004 / Interspecies transmission of an H7N3 influenza virus from wild birds to intensively reared domestic poultry in Italy / Virology 323:24~36
Chen GW / 2006 / Genomic signatures of human versus avian influenza A viruses / Emerg Infect Dis 12:1353~1360
Chen W / 2001 / A novel influenza A virus mitochondrial protein that induces cell death / Nat Med 7:1306~1312
Cheung CL / 2006 / Distribution of amantadine-resistant H5N1 avian influenza variants in Asia / J Infect Dis 193:1626~1629
Campitelli L / 2004 / Interspecies transmission of an H7N3 influenza virus from wild birds to intensively reared domestic poultry in Italy / Virology 323:24~36
Chen GW / 2006 / Genomic signatures of human versus avian influenza A viruses / Emerg Infect Dis 12:1353~1360
Chen W / 2001 / A novel influenza A virus mitochondrial protein that induces cell death / Nat Med 7:1306~1312
Cheung CL / 2006 / Distribution of amantadine-resistant H5N1 avian influenza variants in Asia / J Infect Dis 193:1626~1629
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UCI(KEPA) : I410-ECN-0101-2014-520-002807570