지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.85 No.4
- 발행연도
- 2013.10
- 수록면
- 154 - 160 (7page)
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초록· 키워드
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Purpose: This study evaluated the efficacy of neoadjuvant chemotherapy combining 5-flurouracil/folinic acid with irinotecan (FOLFIRI) in colorectal multiple liver metastases regardless of resectability.
Methods: Forty-four patients with multiple (at least two) colorectal liver metastases were enrolled at seven tertiary referral hospitals between May 2007 and September 2010. All patients received the FOLFIRI chemotherapeutic regimen. Response to chemotherapy was assessed after three cycles (6 weeks) and once more after six cycles (12 weeks) of treatment.
Results: Objective response was noted in 27 patients (61.4%) and 4 patients (9.1%) had progressive disease. Of 44 patients, 10 patients (22.7%) underwent curative surgery (R0 resection) and 34 patients did not receive R0 resection. Grades 3 to 4 hematological toxicity was noted in 12 patients (27.3%) and grades 3 to 4 nonhematologic toxicity was identified in 5 patients (11.4%).
Conclusion: FOLFIRI chemotherapy as a neoadjuvant chemotherapy for multiple colorectal liver metastases regardless of resectability demonstrated the possibility of R0 resection, high rate of objective response, and tolerable toxicities in this study.
Methods: Forty-four patients with multiple (at least two) colorectal liver metastases were enrolled at seven tertiary referral hospitals between May 2007 and September 2010. All patients received the FOLFIRI chemotherapeutic regimen. Response to chemotherapy was assessed after three cycles (6 weeks) and once more after six cycles (12 weeks) of treatment.
Results: Objective response was noted in 27 patients (61.4%) and 4 patients (9.1%) had progressive disease. Of 44 patients, 10 patients (22.7%) underwent curative surgery (R0 resection) and 34 patients did not receive R0 resection. Grades 3 to 4 hematological toxicity was noted in 12 patients (27.3%) and grades 3 to 4 nonhematologic toxicity was identified in 5 patients (11.4%).
Conclusion: FOLFIRI chemotherapy as a neoadjuvant chemotherapy for multiple colorectal liver metastases regardless of resectability demonstrated the possibility of R0 resection, high rate of objective response, and tolerable toxicities in this study.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Boyle P / 2000 / ABC of colorectal cancer: Epidemiology / BMJ 321 : 805 ~ 808
2. [학술지(정기간행물)] - Landis SH / 1999 / Cancer statistics, 1999 / CA Cancer J Clin 49 : 8 ~ 31
3. [학술지(정기간행물)] - Steele G Jr / 1989 / Resection of hepatic metastases from colorectal cancer. Biologic perspective / Ann Surg 210 : 127 ~ 138
4. [학술지(정기간행물)] - Abdalla EK / 2004 / Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases / Ann Surg 239 : 818 ~ 825
5. [학술지(정기간행물)] - Choti MA / 2002 / Trends in long-term survival following liver resection for hepatic colorectal metastases / Ann Surg 235 : 759 ~ 766
2. [학술지(정기간행물)] - Landis SH / 1999 / Cancer statistics, 1999 / CA Cancer J Clin 49 : 8 ~ 31
3. [학술지(정기간행물)] - Steele G Jr / 1989 / Resection of hepatic metastases from colorectal cancer. Biologic perspective / Ann Surg 210 : 127 ~ 138
4. [학술지(정기간행물)] - Abdalla EK / 2004 / Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases / Ann Surg 239 : 818 ~ 825
5. [학술지(정기간행물)] - Choti MA / 2002 / Trends in long-term survival following liver resection for hepatic colorectal metastases / Ann Surg 235 : 759 ~ 766
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UCI(KEPA) : I410-ECN-0101-2014-510-002804944