지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 297 - 304 (8page)
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초록· 키워드
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Trichinosis is a parasitic zoonosis caused by the nematode Trichinella spiralis. Anthelmintics are used to eliminate intestinal adults as well as tissue-migrating and encysted larvae. This study aimed to investigate the effects of ivermectin and myrrh obtained from the aloe-gum resin of Commiphora molmol on experimental trichinosis. Ninety albino mice were orally infected with 300 T. spiralis larvae. Drugs were tested against adult worms at day 0 and day 5 and against encysted larvae on day 15 and day 35 post-infection (PI). Mature worms and encysted larvae were counted in addition to histopathological examination of muscle specimens. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein, albumin, globulin, urea, and creatinine values were estimated. Significant reductions in mean worm numbers were detected in ivermectin treated mice at day 0 and day 5 PI achieving efficacies of 98.5% and 80.0%, while efficacies of myrrh in treated mice were 80.7% and 51.5%, respectively. At days 15 and 35 post-infection, ivermectin induced significant reduction in encysted larval counts achieving efficacies of 76.5% and 54.0%, respectively, while myrrh efficacies were 76.6% and 35.0%, respectively. AST, ALT, urea, and creatinine levels were reduced, while total proteins were increased in response to both treatments compared to their values in the infected non-treated mice. Ivermectin use for controlling T. spiralis could be continued. Myrrh was effective and could be a promising drug against the Egyptian strains of T. spiralis with results nearly comparable to ivermectin.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Murrell KD / 2001 / Trichinellosis: now and forevermore? / Parasite 8 : S11 ~ S13
2. [학술지(정기간행물)] - Hosking BC / 1996 / Multigeneric resistance to oxfendazole by nematodes in cattle / Vet Rev 138 : 67 ~ 68
3. [학술지(정기간행물)] - Teppema JS / 1973 / Ultrastructural aspects of capsule formation in Trichinella spiralis infection in the rat / Parasitology 66 : 291 ~ 296
4. [학술지(정기간행물)] - Cabié A / 1996 / Albendazole versus thiabendazole as therapy for trichinosis: A retrospective study / Clin Infect Dis 22 : 1033 ~ 1035
5. [학술지(정기간행물)] - Campbell WC / 1974 / Chemotherapy of Trichinella spiralis infections (a review) / Exp Parasitol 35 : 304 ~ 334
2. [학술지(정기간행물)] - Hosking BC / 1996 / Multigeneric resistance to oxfendazole by nematodes in cattle / Vet Rev 138 : 67 ~ 68
3. [학술지(정기간행물)] - Teppema JS / 1973 / Ultrastructural aspects of capsule formation in Trichinella spiralis infection in the rat / Parasitology 66 : 291 ~ 296
4. [학술지(정기간행물)] - Cabié A / 1996 / Albendazole versus thiabendazole as therapy for trichinosis: A retrospective study / Clin Infect Dis 22 : 1033 ~ 1035
5. [학술지(정기간행물)] - Campbell WC / 1974 / Chemotherapy of Trichinella spiralis infections (a review) / Exp Parasitol 35 : 304 ~ 334
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UCI(KEPA) : I410-ECN-0101-2014-510-002777720