지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 389 - 400 (12page)
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초록· 키워드
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Korean Red Ginseng (KRG) has been reported to exert anticancer, anti-oxidant, and anti-inflammatory effects. However, there has been no report on the effect of KRG on skin pigmentation. In this study, we investigated the inhibitory effect of KRG on melanocyte proliferation. KRG extract (KRGE) at different concentrations had no effect on melanin synthesis in melan-A melanocytes. Saponin of KRG (SKRG) inhibited melanin content to 80% of the control at 100 ppm. Keratinocyte-derived factors induced by UV-irradiation were reported to stimulate melanogenesis, differentiation, proliferation, and dendrite formation. In this study, treatment of melan-A melanocytes with conditioned media from UV-irradiated SP-1 keratinocytes increased melanocyte proliferation. When UV-irradiated SP-1 keratinocytes were treated with KRGE or SKRG, the increase of melanocyte proliferation by the conditioned media was blocked. Granulocyte-macrophage colony-stimulating factor (GM-CSF) was produced and released from UV-irradiated keratinocytes. This factor has been reported to be involved in regulating the proliferation and differentiation of epidermal melanocytes. In this study, GM-CSF was significantly increased in SP-1 keratinocytes by UVB irradiation (30 mJ/cm2), and the proliferation of melan-A melanocytes increased significantly by GM-CSF treatment. In addition, the proliferative effect of keratinocyte-conditioned media on melan-A melanocytes was blocked by anti-GM-CSF treatment. KRGE or SKRG treatment decreased the expression of GM-CSF in SP-1 keratinocytes induced by UVB irradiation. These results demonstrate that UV irradiation induced GM-CSF expression in keratinocytes and KRGE or SKRG inhibited its expression. Therefore, KRG could be a good candidate for regulating UV-induced melanocyte proliferation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (59)
참고문헌 신청
1. [학술지(정기간행물)] - Attele AS / 1999 / Ginseng pharmacology: multiple constituents and multiple actions / Biochem Pharmacol 58 : 1685 ~ 1693
2. [학술지(정기간행물)] - Tachikawa E / 1999 / Effects of ginseng saponins on responses induced by various receptor stimuli / Eur J Pharmacol 369 : 23 ~ 32
3. [학술지(정기간행물)] - Hua Yin / 2011 / Korean Red Ginseng Extract Activates Non-NMDA Glutamate and GABAA Receptors on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Mice / Journal of Ginseng Research 35 (2) : 219 ~ 225
4. [학술지(정기간행물)] - Yun TK. / 2001 / Brief introduction of Panax ginseng C.A. Meyer / J Korean Med Sci 16 (Suppl) : S3 ~ S5
5. [학술지(정기간행물)] - Kyung Goo Lee / 2011 / Efficacy of Korean Red Ginseng in the Treatment of Atopic Dermatitis / Journal of Ginseng Research 35 (2) : 149 ~ 154
2. [학술지(정기간행물)] - Tachikawa E / 1999 / Effects of ginseng saponins on responses induced by various receptor stimuli / Eur J Pharmacol 369 : 23 ~ 32
3. [학술지(정기간행물)] - Hua Yin / 2011 / Korean Red Ginseng Extract Activates Non-NMDA Glutamate and GABAA Receptors on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Mice / Journal of Ginseng Research 35 (2) : 219 ~ 225
4. [학술지(정기간행물)] - Yun TK. / 2001 / Brief introduction of Panax ginseng C.A. Meyer / J Korean Med Sci 16 (Suppl) : S3 ~ S5
5. [학술지(정기간행물)] - Kyung Goo Lee / 2011 / Efficacy of Korean Red Ginseng in the Treatment of Atopic Dermatitis / Journal of Ginseng Research 35 (2) : 149 ~ 154
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UCI(KEPA) : I410-ECN-0101-2014-520-002777880