Purpose: This study was done to investigate nurses" awareness of death and the meaning of life and identify factors influencing the meaning of life. Methods: Participants were 198 women nurses who had experienced the death of patients. They answered a self-administered questionnaire including demographics, awareness of death scale and meaning in life II scale. Data were analyzed using descriptive statistics, t-test, ANOVA, Scheffe test, and multiple regression (enter method). Results: The average score for awareness of death was 127.3±10.14. This score is moderate not biased toward positive or negative. The average score for meaning of life was 130.3±9.42 with 51% for loss steps, 45.5% for pursuit steps and 3.5% for discovery steps to the meaning of life. Factors affecting the meaning of life were religion, Buddhism (β =6.25, p=.015) or Atheist (β =5.91, p=.017), educational level, Master"s or higher (β =16.22, p=.003), work department, special department (β =3.49, p=.017). Conclusions: Results of the study indicate a need to provide nursing programs that will promote nurses" spiritual and inner maturity.